Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/236102
Type: Artigo de periódico
Title: Alternatives For Reducing Relapse Rate When Switching From Natalizumab To Fingolimod In Multiple Sclerosis.
Author: Fragoso, Yara Dadalti
Adoni, Tarso
Alves-Leon, Soniza Vieira
Apostolos-Pereira, Samira Luisa
de Araujo, Yuna Ribeiro
Becker, Jefferson
Bidin Brooks, Joseph Bruno
Correa, Eber Castro
Damasceno, Alfredo
de Albuquerque Damasceno, Carlos Augusto
Ferreira, Maria Lucia B
da Gama, Paulo Diniz
Diniz da Gama, Rodrigo Assad
Gomes, Sidney
Magno Goncalves, Marcus Vinicius
Grzesiuk, Anderson Kuntz
Nunes Machado, Suzana Costa
da Cunha Matta, Andre Palma
Mendes, Maria Fernanda
Goncalves Jube Ribeiro, Taysa Alexandrino
da Rocha, Cristiane Franklin
Ruocco, Heloisa Helena
Sato, Henry
Simm, Renata Faria
Tauil, Carlos Bernardo
Ferreira Vasconcelos, Claudia Cristina
Ferreira Vieira, Vera Lucia
Abstract: Natalizumab is a therapeutic option for treating multiple sclerosis (MS) and is particularly efficacious for patients with highly active disease. A long washout period has been recommended between withdrawal of natalizumab and start of fingolimod (another option for treating MS). This long washout period has been associated with a significant increase in MS activity. In the present study, a group of 96 patients who were switched from natalizumab to fingolimod had short washout periods between drugs, or monthly corticosteroid pulse therapy if longer washout periods were recommended. This therapeutic approach led to the lowest reported relapse rate so far, among patients with MS switching from natalizumab to fingolimod (8.3%). No complications from short withdrawal were observed in this group of patients.
Subject: Fingolimod
Multiple Sclerosis
Natalizumab
Progressive Multifocal Leukoencephalopathy
Citation: Expert Review Of Clinical Pharmacology. v. 9, n. 4, 2016-Jan.
Rights: embargo
Identifier DOI: 10.1586/17512433.2016.1145053
Address: http://www.ncbi.nlm.nih.gov/pubmed/26794493
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.