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Type: Artigo de periódico
Title: Tautomerism In 8-nitroguanosine Studied By Nmr And Theoretical Calculations.
Author: Barbosa, Thaís M
Rittner, Roberto
Alexander, Katie
Cosstick, Richard
Abraham, Raymond J
Abstract: The guanine base in DNA, due to its low oxidation potential, is particularly sensitive to chemical modifications. A large number of guanine lesions have been characterized and studied in some detail due to their relationship with tissue inflammations. Nevertheless, one example of these lesions is the formation of 8-nitro-guanosine, but the NMR data of this compound was only partially interpreted. A comprehensive study of the two possible tautomeric forms, through a detailed characterization of this compound, has implications for its base pairing properties. The target compound was obtained through a synthetic sequence of five steps, where all intermediates were fully characterized using spectral data. The analysis of the two tautomers was then evaluated through NMR spectroscopy and theoretical calculations of the chemical shifts and NH coupling constants, which were also compared with the data from guanosine.
Subject: Dna Lesions
Theoretical Calculations
Citation: Nucleosides, Nucleotides & Nucleic Acids. v. 35, n. 2, p. 1-11, 2016-Jan.
Rights: embargo
Identifier DOI: 10.1080/15257770.2015.1114127
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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