Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/236066
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampSilva, Camila Batista dapt_BR
dc.contributor.authorunicampGroppo, Francisco Carlospt_BR
dc.contributor.authorunicampSantos, Cleiton Pita dospt_BR
dc.contributor.authorunicampSerpe, Lucianopt_BR
dc.contributor.authorunicampFranz-Montan, Michellept_BR
dc.contributor.authorunicampPaula, Eneida dept_BR
dc.contributor.authorunicampRanali, Josépt_BR
dc.contributor.authorunicampVolpato, Maria Cristinapt_BR
dc.typeArtigopt_BR
dc.titleAnaesthetic efficacy of unilamellar and multilamellar liposomal formulations of articaine in inflamed and uninflamed tissue.pt_BR
dc.contributor.authorda Silva, Camila Batistapt_BR
dc.contributor.authorGroppo, Francisco Carlospt_BR
dc.contributor.authorDos Santos, Cleiton Pitapt_BR
dc.contributor.authorSerpe, Lucianopt_BR
dc.contributor.authorFranz-Montan, Michellept_BR
dc.contributor.authorde Paula, Eneidapt_BR
dc.contributor.authorRanali, Josépt_BR
dc.contributor.authorVolpato, Maria Cristinapt_BR
dc.subjectAnestesia localpt_BR
dc.subjectAnestesia dentáriapt_BR
dc.subjectCarticaínapt_BR
dc.subjectAdrenalinapt_BR
dc.subjectLipossomas unilamelarespt_BR
dc.subject.otherlanguageAnesthesia, localpt_BR
dc.subject.otherlanguageDental Anaesthesiapt_BR
dc.subject.otherlanguageCarticainept_BR
dc.subject.otherlanguageAdrenalinept_BR
dc.subject.otherlanguageUnilamellar liposomespt_BR
dc.description.abstractWe compared the efficacy of articaine encapsulated in multilamellar and unilamellar liposomes with that of articaine with epinephrine, after infiltration into inflamed and uninflamed tissue in rats. We encapsulated 4% articaine in multilamellar (articaine:multi) and unilamellar (articaine:uni) liposomes and compared them with 4% articaine with 1:100 000 epinephrine (articaine:epinephrine), in inflamed (plantar incision into the hind paw) and uninflamed (infraorbital nerve block) tissue in rats. Anaesthetic formulations (0.1ml) were injected near the right infraorbital foramen in uninflamed tissue, where success and duration of anaesthesia were assessed by pinching the upper lip every 5minutes. For inflamed tissue the anaesthetic formulations (0.1ml) were injected laterally into a surgical wound made 24hours earlier in the plantar region of the rat's right hind paw. The degree of anaesthesia was assessed by application of forces laterally to the wound with electronic von Frey filaments. Articaine:uni resulted in less successful anaesthesia than both articaine:multi (p=1.1x10(-5)) and articaine:epinephrine (p=4.3x10(-8)) in uninflamed tissue, but there were no differences in duration or success of anaesthesia between articaine:epinephrine and articaine:multi. In inflamed tissue articaine:epinephrine gave significantly more effective anaesthesia for longer than aarticaine:uni (p=2.3x10(-6)), and articaine:epinephrine (p=1.8x10(-6)) formulations, which did not differ from each other. Multilamellar liposomal articaine could be an option for local anaesthesia in uninflamed tissues. However, articaine with epinephrine gave better results than liposomal formulations in inflamed tissue.en
dc.description.abstractWe compared the efficacy of articaine encapsulated in multilamellar and unilamellar liposomes with that of articaine with epinephrine, after infiltration into inflamed and uninflamed tissue in rats. We encapsulated 4% articaine in multilamellar (articaine:multi) and unilamellar (articaine:uni) liposomes and compared them with 4% articaine with 1:100 000 epinephrine (articaine:epinephrine), in inflamed (plantar incision into the hind paw) and uninflamed (infraorbital nerve block) tissue in rats. Anaesthetic formulations (0.1ml) were injected near the right infraorbital foramen in uninflamed tissue, where success and duration of anaesthesia were assessed by pinching the upper lip every 5minutes. For inflamed tissue the anaesthetic formulations (0.1ml) were injected laterally into a surgical wound made 24hours earlier in the plantar region of the rat's right hind paw. The degree of anaesthesia was assessed by application of forces laterally to the wound with electronic von Frey filaments. Articaine:uni resulted in less successful anaesthesia than both articaine:multi (p=1.1x10(-5)) and articaine:epinephrine (p=4.3x10(-8)) in uninflamed tissue, but there were no differences in duration or success of anaesthesia between articaine:epinephrine and articaine:multi. In inflamed tissue articaine:epinephrine gave significantly more effective anaesthesia for longer than aarticaine:uni (p=2.3x10(-6)), and articaine:epinephrine (p=1.8x10(-6)) formulations, which did not differ from each other. Multilamellar liposomal articaine could be an option for local anaesthesia in uninflamed tissues. However, articaine with epinephrine gave better results than liposomal formulations in inflamed tissuept
dc.relation.ispartofBritish journal of oral and maxillofacial surgerypt_BR
dc.relation.ispartofabbreviationBr. j. ora.l maxillofac. surg.pt_BR
dc.publisher.cityOxfordpt_BR
dc.publisher.countryReino Unidopt_BR
dc.publisherElsevierpt_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationApr.pt_BR
dc.identifier.citationThe British Journal Of Oral & Maxillofacial Surgery. v. 54, n. 3, 2016-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume54pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage295pt_BR
dc.description.lastpage300pt_BR
dc.rightsfechadopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn0266-4356pt_BR
dc.identifier.eissn1532-1940pt_BR
dc.identifier.doi10.1016/j.bjoms.2016.01.005pt_BR
dc.identifier.urlhttps://www.sciencedirect.com/science/article/pii/S0266435616000073pt_BR
dc.description.sponsorshipFAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsordocumentnumber2006/00121-9; 2009/11842-7pt_BR
dc.date.available2016-05-23T19:43:49Z-
dc.date.accessioned2016-05-23T19:43:49Z-
dc.description.provenanceMade available in DSpace on 2016-05-23T19:43:49Z (GMT). No. of bitstreams: 1 pmed_26826985.pdf: 600213 bytes, checksum: 93bd00536b0802dedeca7695c5d602e1 (MD5) Previous issue date: 2016 Bitstreams deleted on 2020-05-14T20:38:56Z: pmed_26826985.pdf,. Added 1 bitstream(s) on 2020-05-14T20:43:16Z : No. of bitstreams: 1 26826985.pdf: 475443 bytes, checksum: 3ab9551a1c210d998ea962ee291ef634 (MD5) Bitstreams deleted on 2020-06-04T12:48:12Z: 26826985.pdf,. Added 1 bitstream(s) on 2020-06-04T12:53:25Z : No. of bitstreams: 1 26826985.pdf: 1085219 bytes, checksum: 9a77d0adcf5b9709b8e0d35628dcbcfa (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/236066-
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentsem informaçãopt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentDepartamento de Bioquímica e Biologia Tecidualpt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.departmentDepartamento de Ciências Fisiológicaspt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeInstituto de Biologiapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.contributor.unidadeFaculdade de Odontologia de Piracicabapt_BR
dc.subject.keywordArticainept_BR
dc.subject.keywordEpinephrinept_BR
dc.identifier.source26826985-
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0002-8513-773Xpt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcidsem informaçãopt_BR
dc.creator.orcid0000-0003-0760-1389pt_BR
dc.creator.orcid0000-0003-4504-5723pt_BR
dc.creator.orcid0000-0002-4623-000Xpt_BR
dc.creator.orcid0000-0002-1459-7050pt_BR
dc.type.formArtigopt_BR
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