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Type: Artigo de periódico
Title: Membranous Nephropathy And Cerebellar Degeneration With Anti-gad Antibodies In Type 2 Diabetes Mellitus.
Author: Folli, Franco
Daniele, Giuseppe
Werner, Sherry
Kamath, Subash
Munera, Jose Velez
Abboud, Hanna
Fanti, Paolo
Abstract: To study the potential pathogenic significance of the coexistence of membranous nephropathy, cerebellar degeneration and anti-glutamic acid decarboxylase (GAD) autoantibodies in patients with diabetes. We performed a direct immunocytochemistry on human kidney slides, electron microscopy on human kidney biopsy, direct immunofluorescence on human kidney biopsy. Baboon and rat kidney cell lines were fractionated and subjected to western blotting with antibodies to GAD. In this patient we demonstrate the presence of autoantibodies to GAD, which is highly enriched in podocytes plasma membrane and tubular cells of the kidney as well as sub-endothelial IgG and complement C3 deposits in the glomerular basement membrane (GBM). We hypothesize the existence in this patient of a common autoimmune pathogenic mechanism with GAD as the autoantigenic determinant, underlying cerebellar degeneration and membranous nephropathy.
Subject: Anti-glutamic Acid Decarboxylase (gad) Autoantibodies
Cerebellar Degeneration
Membranous Nephropathy
Type 2 Diabetes Mellitus
Rights: fechado
Identifier DOI: 10.1007/s00592-015-0728-x
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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