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Type: Artigo de periódico
Title: Death Or Survival With Major Morbidity In Vlbw Infants Born At Brazilian Neonatal Research Network Centers.
Author: Guinsburg, Ruth
de Almeida, Maria Fernanda Branco
de Castro, Junia Sampel
Silveira, Rita C
Caldas, Jamil Pedro de Siqueira
Fiori, Humberto Holmer
Vale, Marynéa Silva do
Abdallah, Vânia Olivetti Steffen
Cardoso, Laura Emilia Monteiro Bigélli
Alves Filho, Navantino
Moreira, Maria Elisabeth
Acquesta, Ana Lucia
Ferrari, Lígia S Lopes
Bentlin, Maria Regina
Venzon, Paulyne Stadler
Gonçalves Ferri, Walusa Assad
Meneses, Jucille do Amaral
Diniz, Edna Maria De Albuquerque
Zanardi, Dulce Maria Toledo
Dos Santos, Cristina Nunes
Bandeira Duarte, José Luiz
Rego, Maria Albertina Santiago
Abstract: To analyze unfavorable outcomes at hospital discharge of preterm infants born at Brazilian public university centers. Prospective cohort of 2646 inborn infants with gestational age 23-33 weeks and birth weight 400-1499 g, without malformations, born at 20 centers in 2012-2013. Unfavorable outcome was defined as in-hospital death or survival at hospital discharge with ≥1 major morbidities: bronchopulmonary dysplasia (BPD) at 36 corrected weeks, intraventricular hemorrhage (IVH) grades 3-4, periventricular leukomalacia (PVL) or surgically treated retinopathy of prematurity (ROP). Among 2646 infants, 1390 (53%) either died or survived with major morbidities: 793 (30%) died; 497 (19%) had BPD; 358 (13%) had IVH 3-4 or PVL; and 84 (3%) had ROP. Logistic regression adjusted by center showed association of unfavorable outcome with: antenatal steroids (OR 0.70; 95%CI 0.55-0.88), C-section (0.72; 0.58-0.90), gestational age <30 (4.00; 3.16-5.07), being male (1.44; 1.19-1.75), small for gestational age (2.19; 1.72-2.78), 5th-min Apgar <7 (3.89; 2.88-5.26), temperature at NICU admission <36.0 °C (1.42; 1.15-1.76), respiratory distress syndrome (3.87; 2.99-5.01), proven late sepsis (1.33; 1.05-1.69), necrotizing enterocolitis (3.10; 2.09-4.60) and patent ductus arteriosus (1.69; 1.37-2.09). More than half of the VLBW infants born at public university level 3 Brazilian hospitals either die or survive with major morbidities.
Subject: Bronchopulmonary Dysplasia
Intraventricular Hemorrhage
Neonatal Mortality
Periventricular Leukomalacia
Preterm Newborn Infant
Retinopathy Of Prematurity
Very Low Birth Weight Newborn Infant
Rights: embargo
Identifier DOI: 10.3109/14767058.2015.1031740
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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