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Type: Artigo de periódico
Title: Royal Jelly And Its Dual Role In Tnbs Colitis In Mice.
Author: Manzo, Luis Paulo
de-Faria, Felipe Meira
Dunder, Ricardo José
Rabelo-Socca, Eduardo Augusto
Consonni, Silvio Roberto
de Almeida, Ana Cristina Alves
Souza-Brito, Alba Regina Monteiro
Luiz-Ferreira, Anderson
Abstract: Royal Jelly (RJ) is widely consumed in diets throughout the world due to its beneficial effects: antioxidant, antitumor and anti-inflammatory. We have investigated the role of RJ in the development of TNBS colitis in mice. Colitis was induced by a rectal instillation of TNBS at 0.1 mL per mouse. Intestine samples of the animals orally treated with RJ (100, 150, and 200 mg/kg) were collected for antioxidant assays (GSH and GSH-Px), proinflammatory protein quantification (COX-2 and NF-κB), and histological analyses. RJ 100 mg/kg maintained GSH levels and increased the activity of GSH-Px, downregulated key inflammatory mediators (COX-2 and NF-κB), and decreased the lesions caused by TNBS as shown by the histological analyses. In conclusion, RJ showed anti-inflammatory and antioxidant properties in experimental colitis, resulting in the amelioration of the macroscopic and histological analyses. These results corroborate with the RJ supplementation in diets.
Citation: Thescientificworldjournal. v. 2015, p. 956235, 2015.
Rights: aberto
Identifier DOI: 10.1155/2015/956235
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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