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Type: Artigo de periódico
Title: Proteínas tirosina fosfatases: propriedades e funções biológicas
Title Alternative: Protein tyrosine phosphatases: properties and biological functions
Author: Aoyama, Hiroshi
Silva, Telma Maria Araújo
Miranda, Márcio André
Ferreira, Carmen Veríssima
Abstract: Protein phosphorylation-dephosphorylation catalyzed by the opposing and dynamic action of protein kinases and phosphatases probably, is the most crucial chemical reaction taking place in living organisms. Protein phosphatases are classified according to their substrate specificity and sensitivity to inhibitory or activator agents, into two families of protein phosphatases: serine/threonine phosphatases and tyrosine phosphatases (PTPs). PTPs can be divided into 3 groups: tyrosine specific phosphatases, dual and low molecular weight phosphatases. The role of tyrosine phosphorylation in mitogenic signaling is well documented, and one would predict that vanadate, pervanadate and other oxidant agents (protein tyrosine phosphatase inhibitors) may act as a growth stimulator.
Subject: protein tyrosine phosphatases
signal transduction
biological function
Editor: Sociedade Brasileira de Química
Citation: Química Nova. Sociedade Brasileira de Química, v. 26, n. 6, p. 896-900, 2003.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422003000600019
Date Issue: 1-Dec-2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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