Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/235821
Type: Artigo
Title: High-fat diet during pregnancy and lactation impairs the cholinergic anti-inflammatory pathway in the liver and white adipose tissue of mouse offspring
Author: Payolla, Tanyara Baliani
Lemes, Simone Ferreira
Fante, Thaís de
Reginato, Andressa
Silva, Cristiano Mendes da
Micheletti, Thayana de Oliveira
Rodrigues, Hosana Gomes
Torsoni, Adriana Souza
Milanski, Marciane
Torsoni, Marcio Albe
Abstract: Cholinergic anti-inflammatory pathway (CAP) prevents inflammatory cytokines production. The main was to evaluate the effect of maternal obesity on cholinergic pathway in the offspring. Female mice were subjected to either standard chow (SC) or high-fat diet (HFD) during pregnancy and the lactation period. After weaning, only male offspring from HFD dams (HFD-O) and from SC dams (SC-O) were fed the SC diet. Key proteins of the CAP were downregulated and serum TNF-α was elevated in the HFD-O mice. STAT3 and NF-κB activation in HFD-O mice ICV injected with nicotine (agonist) were lower than SC-O mice. Basal cholinesterase activity was upregulated in HFD-O mice in both investigated tissues. Lipopolysaccharide increased TNF-α and IL-1β expression in the liver and WAT of SC-O mice, but this effect was greater in HFD-O mice. In conclusion these changes exacerbated cytokine production in response to LPS and contributed to the reduced sensitivity of the CAP.
Cholinergic anti-inflammatory pathway (CAP) prevents inflammatory cytokines production. The main was to evaluate the effect of maternal obesity on cholinergic pathway in the offspring. Female mice were subjected to either standard chow (SC) or high-fat di
metadata.dc.description.abstractalternative: Les cages généralement utilisées en expérimentation animale peuvent empêcher les rats d'adopter la plupart des formes naturelles de comportement locomoteur. Ces animaux ont tendance a` adopter des habitudes sédentaires. Dans cette étude, nous démontrons q
Subject: Via anti-inflamatória colinérgica
Dieta hiperlipídica
Obesidade
Country: Irlanda
Editor: Elsevier
Citation: Molecular And Cellular Endocrinology. v. 422, p. 192-202, 2016-Feb.
Rights: fechado
Identifier DOI: 10.1016/j.mce.2015.12.004
Address: https://www.sciencedirect.com/science/article/pii/S0303720715301593
Date Issue: 2016
Appears in Collections:IB - Artigos e Outros Documentos
FCA - Artigos e Outros Documentos

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