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Type: Artigo de periódico
Title: Enantioselective Total Synthesis Of (+)-lyngbyabellin M.
Author: Pirovani, Rodrigo V
Brito, Gilmar A
Barcelos, Rosimeire C
Pilli, Ronaldo A
Abstract: Lyngbyabellin M is a non-ribosomal peptide synthetase/polyketide synthase derived metabolite isolated from the cyanobacterium M. bouillonii displaying thiazole rings and a distinct chlorinated octanoic acid chain. Its absolute configuration was proposed based on the comparison of its spectroscopic data with those of other representatives of this family of marine natural products, as well as degradation and derivatization studies. Here the first total synthesis of (+)-lyngbyabellin M is described based on the coupling of three key intermediates: two chiral thiazole moieties and an anti hydroxycarboxylic acid prepared stereoselectively via a boron enolate mediated aldol reaction directed by Masamune's chiral auxiliary.
Subject: Chiral Thiazoles
Lyngbyabellin M
Stereoselective Anti Aldol
Total Synthesis
Rights: aberto
Identifier DOI: 10.3390/md13063309
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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