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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleMetabolic And Structural Bone Disturbances Induced By Hyperlipidic Diet In Mice Treated With Simvastatin.pt_BR
dc.contributor.authorSoares, Evelise Alinept_BR
dc.contributor.authorNovaes, Rômulo Diaspt_BR
dc.contributor.authorNakagaki, Wilson Romeropt_BR
dc.contributor.authorFernandes, Geraldo José Medeirospt_BR
dc.contributor.authorGarcia, José Antônio Diaspt_BR
dc.contributor.authorCamilli, José Angelopt_BR
unicamp.authorWilson Romero Nakagaki, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, Brazil.pt_BR
unicamp.authorJosé Angelo Camilli, Department of Structural and Functional Biology, Institute of Biology, State University of Campinas (UNICAMP), Campinas, Brazil.pt_BR
unicamp.author.externalEvelise Aline Soares, Department of Anatomy, Federal University of Alfenas (UNIFAL), Alfenas, Brazil.pt
unicamp.author.externalRômulo Dias Novaes, Department of Structural Biology, Federal University of Alfenas (UNIFAL), Alfenas, Brazil.pt
unicamp.author.externalGeraldo José Medeiros Fernandes, Department of Anatomy, Federal University of Alfenas (UNIFAL), Alfenas, Brazil.pt
unicamp.author.externalJosé Antônio Dias Garcia, Nucleus of Experimental Research in Pharmacology and Experimental Surgery, University José Rosário Vellano (UNIFENAS), Alfenas, Brazil.pt
dc.subjectAnimalspt_BR
dc.subjectBiomechanical Phenomenapt_BR
dc.subjectBone And Bonespt_BR
dc.subjectDiet, High-fatpt_BR
dc.subjectDisease Models, Animalpt_BR
dc.subjectHydroxymethylglutaryl-coa Reductase Inhibitorspt_BR
dc.subjectHyperlipidemiaspt_BR
dc.subjectMalept_BR
dc.subjectMicept_BR
dc.subjectMice, Inbred C57blpt_BR
dc.subjectSimvastatinpt_BR
dc.description.abstractSimvastatin can modulate lipid and bone metabolism. However, information related to the interaction between diet and simvastatin on bone structure and biomechanics is scarce. Thus, this study evaluated the effects of simvastatin on femoral biomechanics and cortical/trabecular bone structure in wild-type mice nourished with a hyperlipidic diet. Three-month-old male wild-type mice (C57BL6 strain) were divided into four groups: (1) group W, nourished with a standard diet; (2) group WH, fed a hyperlipidic diet; (3) group WS, nourished with a standard diet plus oral simvastatin (20 mg/kg/day); and (4) group WHS, fed a hyperlipidic diet plus oral simvastatin (20 mg/kg/day). All animals received only their specific diet and water for 60 days. Blood samples were collected for the analysis of calcium, triglycerides, total cholesterol (TC) and fraction serum levels. Diet manipulation was able to induce a dyslipidaemic status in mice, characterized by triglyceride and TC rise in WH animals. Simvastatin prevented hypercholesterolaemia and reduced TC and LDL serum levels, but did not prevent hypertriglyceridaemia and HDL serum levels in the WHS group. In the WH mice the hyperlipidaemia was associated with reduction in trabecular bone thickness, femur structural and material property alterations. Simvastatin prevented these morphological alterations and minimized femur biomechanical changes in WHS mice. Taken together, the results indicated that the hyperlipidic diet intake acts as a risk factor for bone integrity, generating bones with reduced resistance and more susceptible to fractures, an effect attenuated by simvastatin that is potentially related to the modulatory action of this drug on lipid and bone metabolism.en
dc.relation.ispartofInternational Journal Of Experimental Pathologypt_BR
dc.relation.ispartofabbreviationInt J Exp Patholpt_BR
dc.date.issued2015-Augpt_BR
dc.identifier.citationInternational Journal Of Experimental Pathology. v. 96, n. 4, p. 261-268, 2015-Aug.pt_BR
dc.language.isoengpt_BR
dc.description.volume96pt_BR
dc.description.firstpage261-268pt_BR
dc.rightsembargopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1365-2613pt_BR
dc.identifier.doi10.1111/iep.12134pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/?term=26175225pt_BR
dc.date.available2016-05-23T19:41:48Z-
dc.date.accessioned2016-05-23T19:41:48Z-
dc.description.provenanceMade available in DSpace on 2016-05-23T19:41:48Z (GMT). No. of bitstreams: 1 pmed_26175225.pdf: 506266 bytes, checksum: fad97efd551ca2991d2645ebae4a80af (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235615-
dc.identifier.idPubmed26175225pt_BR
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