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Type: Artigo de periódico
Title: Association Between Maternal Smoking, Gender, And Cleft Lip And Palate.
Author: Martelli, Daniella Reis Barbosa
Coletta, Ricardo D
Oliveira, Eduardo A
Swerts, Mário Sérgio Oliveira
Rodrigues, Laíse A Mendes
Oliveira, Maria Christina
Martelli Júnior, Hercílio
Abstract: Cleft lip and/or palate (CL/P) represent the most common congenital anomalies of the face. To assess the relationship between maternal smoking, gender and CL/P. This is an epidemiological cross-sectional study. We interviewed 1519 mothers divided into two groups: mothers of children with CL/P (n=843) and mothers of children without CL/P (n=676). All mothers were classified as smoker or non-smoker subjects during the first trimester of pregnancy. To determine an association among maternal smoking, gender, and CL/P, odds ratios were calculated and the adjustment was made by a logistic regression model. An association between maternal smoking and the presence of cleft was observed. There was also a strong association between male gender and the presence of cleft (OR=3.51; 95% CI 2.83-4.37). By binary logistic regression analysis, it was demonstrated that both variables were independently associated with clefts. In a multivariate analysis, male gender and maternal smoking had a 2.5- and a 1.5-time greater chance of having a cleft, respectively. Our findings are consistent with a positive association between maternal smoking during pregnancy and CL/P in male gender. The results support the importance of smoking prevention and introduction of cessation programs among women with childbearing potential.
Subject: Cleft Lip
Cleft Palate
Fenda Labial
Fenda Palatina
Hábito De Fumar
Citation: Brazilian Journal Of Otorhinolaryngology. v. 81, n. 5, p. 514-519
Rights: fechado
Identifier DOI: 10.1016/j.bjorl.2015.07.011
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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