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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleA Spring To Summer Shift Of Pro-inflammatory Cytokine Production In Multiple Sclerosis Patients.pt_BR
dc.contributor.authorDamasceno, Alfredopt_BR
dc.contributor.authorMoraes, Adriel Santospt_BR
dc.contributor.authorFarias, Alessandropt_BR
dc.contributor.authorDamasceno, Benito Pereirapt_BR
dc.contributor.authorDos Santos, Leonilda Maria Barbosapt_BR
dc.contributor.authorCendes, Fernandopt_BR
unicamp.authorAlfredo Damasceno, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazilpt_BR
unicamp.authorNeuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas (UNICAMP), Campinas, Brazil. Electronic address: alfredodamasceno@hotmail.com.pt_BR
unicamp.authorAdriel Santos Moraes, Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas (UNICAMP), Campinas, Brazil.pt_BR
unicamp.authorAlessandro Farias, Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas (UNICAMP), Campinas, Brazil.pt_BR
unicamp.authorBenito Pereira Damasceno, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil.pt_BR
unicamp.authorLeonilda Maria Barbosa Dos Santos, Neuroimmunology Unit, Department of Genetics, Evolution and Bioagents, University of Campinas (UNICAMP), Campinas, Brazil.pt_BR
unicamp.authorFernando Cendes, Department of Neurology, University of Campinas (UNICAMP), Campinas, Brazil.pt_BR
dc.subjectChronobiologypt_BR
dc.subjectCytokinespt_BR
dc.subjectImmunologypt_BR
dc.subjectMultiple Sclerosispt_BR
dc.subjectPhenologypt_BR
dc.subjectSeasonal Variationspt_BR
dc.description.abstractHigher MS relapse frequency is observed during warmer months in different regions, but evidence for an underlying immunological variation is lacking. Therefore, we investigated seasonal variations of cytokine production in relapsing-remitting MS patients. Twenty-one patients and eight controls had blood samples drawn in each season, evaluating for IL-10, IL-6, TNF-α and IFN-γ. The lowest levels of cytokine production were observed in spring samples, with a significant increase from spring to summer for most cytokines, and especially IFN-γ and TNF-α. This phenomenon may underlie the higher prevalence of clinical and subclinical MS activity observed in warmer months.en
dc.relation.ispartofJournal Of The Neurological Sciencespt_BR
dc.relation.ispartofabbreviationJ. Neurol. Sci.pt_BR
dc.date.issued2016-Janpt_BR
dc.identifier.citationJournal Of The Neurological Sciences. v. 360, p. 37-40, 2016-Jan.pt_BR
dc.language.isoengpt_BR
dc.description.volume360pt_BR
dc.description.firstpage37-40pt_BR
dc.rightsembargopt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1878-5883pt_BR
dc.identifier.doi10.1016/j.jns.2015.11.022pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/26723969pt_BR
dc.date.available2016-05-23T19:41:05Z-
dc.date.accessioned2016-05-23T19:41:05Z-
dc.description.provenanceMade available in DSpace on 2016-05-23T19:41:05Z (GMT). No. of bitstreams: 1 pmed_26723969.pdf: 539687 bytes, checksum: c4adac98b70735e3c801dad022263567 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/235447-
dc.identifier.idPubmed26723969pt_BR
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