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Type: Artigo de periódico
Title: A Spring To Summer Shift Of Pro-inflammatory Cytokine Production In Multiple Sclerosis Patients.
Author: Damasceno, Alfredo
Moraes, Adriel Santos
Farias, Alessandro
Damasceno, Benito Pereira
Dos Santos, Leonilda Maria Barbosa
Cendes, Fernando
Abstract: Higher MS relapse frequency is observed during warmer months in different regions, but evidence for an underlying immunological variation is lacking. Therefore, we investigated seasonal variations of cytokine production in relapsing-remitting MS patients. Twenty-one patients and eight controls had blood samples drawn in each season, evaluating for IL-10, IL-6, TNF-α and IFN-γ. The lowest levels of cytokine production were observed in spring samples, with a significant increase from spring to summer for most cytokines, and especially IFN-γ and TNF-α. This phenomenon may underlie the higher prevalence of clinical and subclinical MS activity observed in warmer months.
Subject: Chronobiology
Multiple Sclerosis
Seasonal Variations
Citation: Journal Of The Neurological Sciences. v. 360, p. 37-40, 2016-Jan.
Rights: embargo
Identifier DOI: 10.1016/j.jns.2015.11.022
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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