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Type: Artigo de periódico
Title: Evaluation Of The Leishmanicidal And Cytotoxic Effects Of Inhibitors For Microorganism Metabolic Pathway Enzymes.
Author: de Mesquita Barbosa, Ademar
Dos Santos Costa, Solange
da Rocha, Josmar Rodrigues
Montanari, Carlos Alberto
Giorgio, Selma
Abstract: Chemotherapy for leishmaniosis a neglected parasitic disease, is based on few drugs, which are toxic and present resistance issues. Efforts for the development of new therapies are essential for the control of leishmaniasis. Metabolic pathway enzymes are promising targets for new drugs against parasites. The search for effective drugs against key enzymes can take advantage of the similarities between metabolic pathways in different microorganisms trypanosomatids Trypanosoma cruzi and Leishmania and fungus Saccharomyces cerevisiae. In this report, leishmanicidal activity of the metabolic pathway enzymes inhibitors (IDs) of dihydroorotate dehydrogenase (DHODH), glyceraldehyde 3-phosphate dehydrogenase and cruzain-cysteine protease from T. cruzi and scitalona-desidratase, adenosine deaminase, succinate dehydrogenase complex II and hydroxynaphthalene reductase from S. cerevisiae was performed on Leishmania amazonensis extracellular promastigotes and amastigotes within macrophages. The most promising compound, ID195, which is a DHODH inhibitor was toxic against promastigotes and was selective for amastigotes over host cells.
Subject: Dihydroorotate Dehydrogenase
Leishmania Amazonensis
Metabolic Pathway Enzymes Inhibitors
Rights: embargo
Identifier DOI: 10.1016/j.biopha.2015.07.040
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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