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Type: Artigo de periódico
Title: Update On The 2012 Brazilian Society Of Rheumatology Guidelines For The Treatment Of Rheumatoid Arthritis: Position On The Use Of Tofacitinib.
Author: Mota, Licia Maria Henrique da
Cruz, Bóris Afonso
Albuquerque, Cleandro Pires de
Gonçalves, Deborah Pereira
Laurindo, Ieda Maria Magalhães
Pereira, Ivanio Alves
Carvalho, Jozélio Freire de
Pinheiro, Geraldo da Rocha Castelar
Bertolo, Manoel Barros
Pinto, Maria Raquel da Costa
Louzada-Junior, Paulo
Xavier, Ricardo Machado
Giorgi, Rina Dalva Neubarth
Lima, Rodrigo Aires Corrêa
Abstract: In 2014, tofacitinib, a target-specific, synthetic disease modifying anti rheumatic drug (DMARD) and a selective inhibitor of Janus kinase (JAK) was approved for use in Brazil. This position paper aims to update the recommendations of the Brazilian Society of Rheumatology (SBR) on the treatment of rheumatoid arthritis (RA) in Brazil, specifically regarding the use of target-specific synthetic DMARDs. The method of this recommendation consisted of a literature review of scientific papers held on the Medline database. After this review, a text was produced, answering questions in Pico structure, considering efficacy and safety issues of tofacitinib use for RA treatment in different scenarios (such as first-line treatment after failure with methotrexate [MTX] or other conventional synthetic DMARDs after failure with biological therapy). Based on existing evidence, and considering the available data on efficacy, safety and cost of medications available to treat the disease in Brazil, the RA Commission of SBR, after a process of discussion and voting on proposals, established the following position on the use of tofacitinib for treatment of RA in Brazil: Tofacitinib, alone or in combination with MTX, is an alternative for RA patients with moderate or high activity after failure of at least two different synthetic DMARDs and one biological DMARD. The level of agreement with this recommendation was 7.5. This position may be reviewed in the coming years, in the face of a greater experience with the use of this medication.
Subject: Artrite Reumatoide
Rheumatoid Arthritis
Rights: embargo
Identifier DOI: 10.1016/j.rbr.2015.08.004
Date Issue: -1-Uns- -1
Appears in Collections:Unicamp - Artigos e Outros Documentos

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