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Type: Artigo de periódico
Title: Effect Of Human Adipose Tissue Mesenchymal Stem Cells On The Regeneration Of Ovine Articular Cartilage.
Author: Zorzi, Alessandro R
Amstalden, Eliane M I
Plepis, Ana Maria G
Martins, Virginia C A
Ferretti, Mario
Antonioli, Eliane
Duarte, Adriana S S
Luzo, Angela C M
Miranda, João B
Abstract: Cell therapy is a promising approach to improve cartilage healing. Adipose tissue is an abundant and readily accessible cell source. Previous studies have demonstrated good cartilage repair results with adipose tissue mesenchymal stem cells in small animal experiments. This study aimed to examine these cells in a large animal model. Thirty knees of adult sheep were randomly allocated to three treatment groups: CELLS (scaffold seeded with human adipose tissue mesenchymal stem cells), SCAFFOLD (scaffold without cells), or EMPTY (untreated lesions). A partial thickness defect was created in the medial femoral condyle. After six months, the knees were examined according to an adaptation of the International Cartilage Repair Society (ICRS 1) score, in addition to a new Partial Thickness Model scale and the ICRS macroscopic score. All of the animals completed the follow-up period. The CELLS group presented with the highest ICRS 1 score (8.3 ± 3.1), followed by the SCAFFOLD group (5.6 ± 2.2) and the EMPTY group (5.2 ± 2.4) (p = 0.033). Other scores were not significantly different. These results suggest that human adipose tissue mesenchymal stem cells promoted satisfactory cartilage repair in the ovine model.
Subject: Adult Stem Cell
Regenerative Medicine
Stem Cell Therapy
Tissue Engineering
Citation: International Journal Of Molecular Sciences. v. 16, n. 11, p. 26813-26831, 2015.
Rights: aberto
Identifier DOI: 10.3390/ijms161125989
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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