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Type: Carta
Title: Identification Of Anln As Etv6 Partner Gene In Recurrent T(7;12)(p15;p13): A Possible Role Of Deregulated Anln Expression In Leukemogenesis.
Author: Campregher, Paulo Vidal
Pereira, Welbert de Oliveira
Lisboa, Bianca
Puga, Renato
Helman, Ricardo
Miyagi, Mariana
da Mata, Evelyn Helena Ascendino
Datoguia, Tarcila Santos
Velloso, Elvira Deolinda Rodrigues Pereira
Bacal, Nydia Strachman
Ross, Jeffrey S
Ali, Siraj
Miller, Vincent
Costa, Fernando Ferreira
Hamerschlak, Nelson
Santos, Fabio Pires de Souza
Abstract: The ETV6 gene encodes an ETS family transcription factor that is involved in a myriad of chromosomal rearrangements found in hematological malignancies and other neoplasms. A recurrent ETV6 translocation, previously described in patients with acute myeloid leukemia (AML) (Genes Chromosomes Cancer 51:328-337,2012, Leuk Res 35:e212-214, 2011), whose partner has not been identified is t(7;12)(p15;p13). We herein report that the t(7;12)(p15;p13) fuses ETV6 to ANLN, a gene not previously implicated in the pathogenesis of hematological malignancies, and we demonstrate that this translocation leads to high expression of the fusion transcript in the myeloid and lymphoid lineages.
Citation: Molecular Cancer. v. 14, n. 1, p. 197, 2015.
Rights: aberto
Identifier DOI: 10.1186/s12943-015-0471-5
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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