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Type: Artigo de periódico
Title: Purple Carrot Extract Protects Against Cadmium Intoxication In Multiple Organs Of Rats: Genotoxicity, Oxidative Stress And Tissue Morphology Analyses.
Author: Claudio, Samuel Rangel
Gollucke, Andrea Pittelli Boiago
Yamamura, Hirochi
Morais, Damila Rodrigues
Bataglion, Giovana Anceski
Eberlin, Marcos Nogueira
Peres, Rogerio Correa
Oshima, Celina Tizuko Fujiyama
Ribeiro, Daniel Araki
Abstract: The aim of this study was to investigate if purple carrot extract is able to protect against the noxious activities induced by cadmium exposure in multiple organs of rats. For this purpose, histopathological analysis, genotoxicity and oxidative status were investigated in this setting. A total of twenty Wistar rats weighing 250g on the average, and 8 weeks age were distributed into four groups (n=5), as follows: Control group (non-treated group, CTRL); Cadmium group (Cd) and Purple carrot extract groups at 400mg/L or 800mg/L. Histopathological analysis revealed that liver from animals treated with purple carrot extract improved tissue degeneration induced by cadmium intoxication. Genetic damage was reduced in blood and hepatocytes as depicted by comet and micronucleus assays in animals treated with purple carrot extract. SOD-CuZn and cytocrome C gene expression increased in groups treated with purple carrot extract. Purple carrot extract also reduced the 8OHdG levels in liver cells when compared to cadmium group. Taken together, our results demonstrate that purple carrot extract is able to protect against cadmium intoxication by means of reducing tissue regeneration, genotoxicity and oxidative stress in multiple organs of Wistar rats.
Subject: Cadmium
Oxidative Stress
Purple Carrot
Rights: embargo
Identifier DOI: 10.1016/j.jtemb.2015.08.006
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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