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Type: Artigo de periódico
Title: Analysis of phase transition and dehydration processes of nevirapine
Author: de Oliveira, George G. G.
Ferraz, Humberto G.
Severino, Patricia
Souto, Eliana B.
Abstract: Solid-state characterization of crystalline drugs is an important pre-formulation step for the development and design of solid dosage forms, such as pellets and tablets. In this study, phase transition and dehydration processes of nevirapine have been studied by differential scanning calorimetry and thermogravimetry differential thermal analysis to overcome the problems of drug formulation, namely poor solubility and poor content uniformity. Phase solubility studies elucidated the mechanism of enhanced nevirapine solubility.
Subject: Nevirapine
Differential scanning calorimetry (DSC)
Thermogravimetry differential thermal analysis (TG-DTA)
Solid dosage forms
Editor: Springer
Rights: fechado
Identifier DOI: 10.1007/s10973-011-1424-x
Date Issue: 2012
Appears in Collections:FEQ - Artigos e Outros Documentos

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