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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titleSistema antioxidante envolvendo o ciclo metabólico da glutationa associado a métodos eletroanalíticos na avaliação do estresse oxidativopt_BR
dc.title.alternativeAntioxidant system involving the glutathione metabolic cycle associated to electroanalytical methods in the oxidative stress evaluationen
dc.contributor.authorRover Júnior, Laérciopt_BR
dc.contributor.authorHöehr, Nelci Fenaltipt_BR
dc.contributor.authorVellasco, Adriana Paulapt_BR
dc.contributor.authorKubota, Lauro Tatsuopt_BR
unicamp.authorRover Júnior, Laércio Universidade Estatual de Campinas Estadual de Campinas Faculdade de Ciências Médicaspt_BR
unicamp.authorHöehr, Nelci Fenaltipt_BR
unicamp.authorVellasco, Adriana Paulapt_BR
unicamp.authorKubota, Lauro Tatsuo Universidade Estatual de Campinas Estadual de Campinas Instituto de Químicapt_BR
dc.subjectoxidative stresspt_BR
dc.description.abstractThe most relevant advances on the analytical applications of glutathione determination based on glutathione redox cycle and the antioxidant system are given. The main enzymes that participate of the glutathione metabolism are the glutathione peroxidase and glutathione reductase. The glutathione peroxidase has a major role in the removal of hydrogen peroxide and lipid peroxides from the cells. These enzymes, operating in tandem with catalase and superoxide dismutase promote a scavenging of oxyradical products in tissues minimizing damages caused by these species. Reduced glutathione is the major intracellular thiol found in mammals and changes in the glutathione concentration in biological fluids or tissues may provide a useful marker in certain disorders like hemolytic anemia, myocardial oxidative stress and in the investigation of some kinds of cancers. Particular attention is devoted to the main advantages supplied by biosensors in which there is an incorporation of bioactive materials for the glutathione determination. The correlation between stability and sensitivity of some reduced glutathione electrochemical sensors is discussed.en
dc.relation.ispartofQuímica Novapt_BR
dc.publisherSociedade Brasileira de Químicapt_BR
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 24, n. 1, p. 112-119, 2001.pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.provenanceMade available in DSpace on 2014-07-17T14:50:31Z (GMT). No. of bitstreams: 0 Previous issue date: 2001-02-01en
dc.description.provenanceMade available in DSpace on 2015-11-26T11:43:38Z (GMT). No. of bitstreams: 2 S0100-40422001000100019.pdf: 70233 bytes, checksum: 06fab171c195f01782b5342e1a87d401 (MD5) S0100-40422001000100019.pdf.txt: 47321 bytes, checksum: 96fd2d48da46b63b1c5d49822e3d9094 (MD5) Previous issue date: 2001-02-01en
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