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Type: Artigo de periódico
Title: Sistema antioxidante envolvendo o ciclo metabólico da glutationa associado a métodos eletroanalíticos na avaliação do estresse oxidativo
Title Alternative: Antioxidant system involving the glutathione metabolic cycle associated to electroanalytical methods in the oxidative stress evaluation
Author: Rover Júnior, Laércio
Höehr, Nelci Fenalti
Vellasco, Adriana Paula
Kubota, Lauro Tatsuo
Abstract: The most relevant advances on the analytical applications of glutathione determination based on glutathione redox cycle and the antioxidant system are given. The main enzymes that participate of the glutathione metabolism are the glutathione peroxidase and glutathione reductase. The glutathione peroxidase has a major role in the removal of hydrogen peroxide and lipid peroxides from the cells. These enzymes, operating in tandem with catalase and superoxide dismutase promote a scavenging of oxyradical products in tissues minimizing damages caused by these species. Reduced glutathione is the major intracellular thiol found in mammals and changes in the glutathione concentration in biological fluids or tissues may provide a useful marker in certain disorders like hemolytic anemia, myocardial oxidative stress and in the investigation of some kinds of cancers. Particular attention is devoted to the main advantages supplied by biosensors in which there is an incorporation of bioactive materials for the glutathione determination. The correlation between stability and sensitivity of some reduced glutathione electrochemical sensors is discussed.
Subject: glutathione
oxidative stress
Editor: Sociedade Brasileira de Química
Citation: Química Nova. Sociedade Brasileira de Química, v. 24, n. 1, p. 112-119, 2001.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422001000100019
Date Issue: 1-Feb-2001
Appears in Collections:Unicamp - Artigos e Outros Documentos

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