Please use this identifier to cite or link to this item:
|Type:||Artigo de periódico|
|Title:||Analysis of the histologic features in the differential diagnosis of intrahepatic neonatal cholestasis|
|Author:||BELLOMO-BRANDAO, Maria Angela|
ESCANHOELA, Cecilia A. F.
MEIRELLES, Luciana R.
|Abstract:||AIM: To compare the histologic features of the liver in intrahepatic neonatal cholestasis (IHNC) with infectious, genetic-endocrine-metabolic, and idiopathic etiologies. METHODS: Liver biopsies from 86 infants with IHNC were evaluated. The inclusion criteria consisted of jaundice beginning at 3 mo of age and a hepatic biopsy during the 1st year of life. The following histologic features were evaluated: cholestasis, eosinophilia, giant cells, erythropoiesis, siderosis, portal fibrosis, and the presence of a septum. RESULTS: Based on the diagnosis, patients were classified into three groups: group 1 (infectious; n = 18), group 2 (genetic-endocrine-metabolic; n = 18), and group 3 (idiopathic; n = 50). There were no significant differences with respect to the following variables: cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and presence of a septum. A significant difference was observed with respect to erythropoiesis, which was more severe in group 1 (Fisher's exact test, P = 0.016). CONCLUSION: A significant difference was observed in IHNC of infectious etiology, in which erythropoiesis was more severe than that in genetic-endocrine-metabolic and idiopathic etiologies, whereas there were no significant differences among cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and the presence of a septum. (C) 2009 The WIG Press and Baishideng. All rights reserved.|
Neonatal liver disease
|Editor:||W J G PRESS|
|Citation:||WORLD JOURNAL OF GASTROENTEROLOGY, v.15, n.4, p.478-483, 2009|
|Appears in Collections:||FCM - Artigos e Materiais de Revistas Científicas|
Files in This Item:
|art_BELLOMO-BRANDAO_Analysis_of_the_histologic_features_in_the_2009.pdf||published version||780.65 kB||Adobe PDF||View/Open|
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.