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Type: Artigo de periódico
Title: Analysis of the histologic features in the differential diagnosis of intrahepatic neonatal cholestasis
Author: BELLOMO-BRANDAO, Maria Angela
PORTA, Gilda
HESSEL, Gabriel
Abstract: AIM: To compare the histologic features of the liver in intrahepatic neonatal cholestasis (IHNC) with infectious, genetic-endocrine-metabolic, and idiopathic etiologies. METHODS: Liver biopsies from 86 infants with IHNC were evaluated. The inclusion criteria consisted of jaundice beginning at 3 mo of age and a hepatic biopsy during the 1st year of life. The following histologic features were evaluated: cholestasis, eosinophilia, giant cells, erythropoiesis, siderosis, portal fibrosis, and the presence of a septum. RESULTS: Based on the diagnosis, patients were classified into three groups: group 1 (infectious; n = 18), group 2 (genetic-endocrine-metabolic; n = 18), and group 3 (idiopathic; n = 50). There were no significant differences with respect to the following variables: cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and presence of a septum. A significant difference was observed with respect to erythropoiesis, which was more severe in group 1 (Fisher's exact test, P = 0.016). CONCLUSION: A significant difference was observed in IHNC of infectious etiology, in which erythropoiesis was more severe than that in genetic-endocrine-metabolic and idiopathic etiologies, whereas there were no significant differences among cholestasis, eosinophilia, giant cells, siderosis, portal fibrosis, and the presence of a septum. (C) 2009 The WIG Press and Baishideng. All rights reserved.
Subject: Intrahepatic cholestasis
Liver histopathology
Neonatal jaundice
Neonatal liver disease
Country: China
Editor: W J G PRESS
Citation: WORLD JOURNAL OF GASTROENTEROLOGY, v.15, n.4, p.478-483, 2009
Rights: aberto
Identifier DOI: 10.3748/wjg.15.478
Date Issue: 2009
Appears in Collections:FCM - Artigos e Outros Documentos

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