Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/2263
Type: Artigo de periódico
Title: Association of postalimentary lipemia with atherosclerotic manifestations
Author: Tentor, J.
Nakamura, R. T.
Gidlund, M.
Barros-Mazon, S.
Harada, L. M.
Zago, V. S.
Oba, J. F.
de Faria, E. C.
Abstract: We identified different lipemic and metabolic responses after the ingestion of a standardized meal by healthy adults and related them to atherosclerotic markers. Samples from 60 normolipidemic adults were collected before and after a liquid meal (40 g fat/m(2) body surface) at 0, 2, 4, 6, and 8 h for measurements of lipids, free fatty acids (FFA), insulin, cholesteryl ester transfer protein (CETP), autoantibodies to epitopes of oxidized LDL (oxLDL Ab), lipolytic activities, and apolipoprotein E polymorphism. Mean carotid intima-media thickness (cIMT) was determined by Doppler ultrasound. The volunteers were classified into early (N = 39) and late (N = 31) triacylglycerol (TAG) responders to the test meal. Late responders showed lower HDL cholesterol concentration at fasting and in the TAG peak, lower insulin and higher FFA concentrations compared to early responders. Multivariate regression analyses showed that mean cIMT was associated with gender (male) and age in early responders and by cholesterol levels at the 6th hour in late responders. oxLDL Ab were explained by lipoprotein lipase and negatively by hepatic lipase and oxLDL Ab (fasting period) by CETP (negative) and FFA (positive). This study is the first to identify a postalimentary insulin resistance state, combined with a reduced CETP response exclusively among late responders, and the identification of the regulators of postalimentary atherogenicity. Further research is required to determine the metabolic mechanisms described in the different postalimentary phenotypes observed in this study, as well as in different pathological states, as currently investigated in our laboratory.
Subject: Postalimentary lipemia
Autoantibodies to epitopes of oxidized LDL
Carotid intima-media thickness
Insulin
Free fatty acids
Country: Brazil
Editor: Assoc Bras Divulg Cientifica
Rights: aberto
Identifier DOI: 10.1590/S0100-879X2012007500127
Date Issue: 2012
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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