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Type: Artigo de periódico
Title: The I405V and Taq1B polymorphisms of the CETP gene differentially affect sub-clinical carotid atherosclerosis
Author: Parra, Eliane Soler
Panzoldo, Natalia Baratella
Kaplan, Denise
Franco de Oliveira, Helena Coutinho
dos Santos, Jose Ernesto
Fernandes de Carvalho, Luiz Sergio
Sposito, Andrei Carvalho
Gidlund, Magnus
Nakamura, Ruy Tsutomu
de Souza Zago, Vanessa Helena
Nakandakare, Edna Regina
Rocha Quintao, Eder Carlos
de Faria, Eliana Cotta
Abstract: Background: Cholesteryl ester transfer protein (CETP) plays a major role in lipid metabolism, but studies on the association of CETP polymorphisms with risks of cardiovascular disease are inconsistent. This study investigated whether the CETP gene I405V and Taq1B polymorphisms modified subclinical atherosclerosis in an asymptomatic Brazilian population sample. Methods: The polymorphisms were analyzed using polymerase chain reaction in 207 adult volunteers. Serum lipid profiles, oxLDL Ab titers, C-reactive protein and tumor necrosis factor-a concentrations and CETP and phospholipid transfer protein (PLTP) activities were determined, and common carotid artery intima-media thickness (cIMT) was measured using ultrasonography. Results: No differences in cIMT were observed between the presence or absence of the minor B2 and V alleles in either polymorphism. However, inverse correlations between mean cIMT and CETP activity in the presence of these polymorphisms were observed, and positive correlations of these polymorphisms with PLTP activity and oxLDL Ab titers were identified. Moreover, logistic multivariate analysis revealed that the presence of the B2 allele was associated with a 5.1-fold (CI 95%, OR: 1.26 - 21.06) increased risk for cIMT, which was equal and above the 66th percentile and positively interacted with age. However, no associations with the V allele or CETP and PLTP activities were observed. Conclusions: None of the studied parameters, including CETP activity, explained the different relationships between these polymorphisms and cIMT, suggesting that other non-determined factors were affected by the genotypes and related to carotid atherosclerotic disease.
Subject: Carotid atherosclerosis
Carotid intima-media thickness
Cholesteryl ester transfer protein
Genetic polymorphism
Editor: Biomed Central Ltd
Citation: Lipids In Health and Disease. Biomed Central Ltd, v.11, 2012
Rights: fechado
Identifier DOI: 10.1186/1476-511X-11-130
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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