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Type: Artigo de periódico
Title: Differential MiRNA expression in childhood acute lymphoblastic leukemia and association with clinical and biological features
Author: de Oliveira, Jaqueline Carvalho
Scrideli, Carlos Alberto
Brassesco, Maria Sol
Morales, Andressa Gois
Pezuk, Julia Alejandra
Queiroz, Rosane de Paula
Yunes, Jose Andres
Brandalise, Silvia Regina
Tone, Luiz Gonzaga
Abstract: The present study aimed to analyze the expression profile of the microRNAs previously described as associated with childhood ALL, miR-92a, miR-100, miR-125a-5p, miR-128a, miR-181b, miR-196b and let-7e, and their association with biological/prognostic features in 128 consecutive samples of childhood acute lymphoblastic leukemia (ALL) by quantitative real-time PCR. A significant association was observed between higher expression levels of miR-196b and T-ALL, miR-100 and patients with low white blood cell count at diagnosis and t(12;21) positive ALL. These findings suggest a potential activity of these microRNAs in pediatric ALL biology. (C) 2011 Elsevier Ltd. All rights reserved.
Subject: MicroRNA
Pediatric acute lymphoblastic leukemia
Prognostic features
Editor: Pergamon-Elsevier Science Ltd
Rights: fechado
Identifier DOI: 10.1016/j.leukres.2011.10.005
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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