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Type: Artigo de periódico
Title: On cytoadhesion of Plasmodium vivax: raison d'être?
Author: Costa, Fabio TM
Lopes, Stefanie CP
Ferrer, Mireia
Leite, Juliana A
Martin-Jaular, Lorena
Bernabeu, Maria
Nogueira, Paulo A
Mourão, Maria Paula G
Fernandez-Becerra, Carmen
Lacerda, Marcus VG
Portillo, Hernando del
Abstract: It is generally accepted that Plasmodium vivax, the most widely distributed human malaria parasite, causes mild disease and that this species does not sequester in the deep capillaries of internal organs. Recent evidence, however, has demonstrated that there is severe disease, sometimes resulting in death, exclusively associated with P. vivax and that P. vivax-infected reticulocytes are able to cytoadhere in vitro to different endothelial cells and placental cryosections. Here, we review the scarce and preliminary data on cytoadherence in P. vivax, reinforcing the importance of this phenomenon in this species and highlighting the avenues that it opens for our understanding of the pathology of this neglected human malaria parasite.
Subject: Plasmodium vivax
severe disease
Editor: Instituto Oswaldo Cruz, Ministério da Saúde
Rights: aberto
Identifier DOI: 10.1590/S0074-02762011000900010
Date Issue: 1-Aug-2011
Appears in Collections:Unicamp - Artigos e Outros Documentos

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