Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/21624
Type: Artigo de periódico
Title: Saponins from Swartzia langsdorffii: biological activities
Author: Magalhães, Aderbal Farias
Tozzi, Ana Maria Goulart de Azevedo
Santos, Celira Caparica
Serrano, Deborah Regina
Zanotti-Magalhães, Eliana Maria
Magalhães, Eva Gonçalves
Magalhães, Luiz Augusto
Abstract: The presence of saponins and the molluscicidal activity of the roots, leaves, seeds and fruits of Swartzia langsdorffii Raddi (Leguminosae) against Biomphalaria glabrata adults and eggs were investigated. The roots, seeds and fruits were macerated in 95% ethanol. These extracts exerted a significant molluscicidal activity against B. glabrata, up to a dilution of 100 mg/l. Four mixtures (A2, B2, C and D) of triterpenoid oleanane type saponins were chromatographically isolated from the seed and fruit extracts. Two known saponins (1 and 2) were identified as beta-D-glucopyranosyl-[alpha-L-rhamnopyranosyl-(1->3)- beta-D-glucuronopyranosyl-(1->3)]-3beta-hydroxyolean-12-ene-28 -oate, and beta-D-glucopyranosyl-(1->3)-beta-D-glucuronopyranosyl-(1 ->3)]-3beta-hydroxyolean-12-ene-28-oate, respectively. These two saponins were present in all the mixtures, together with other triterpenoid oleane type saponins, which were shown to be less polar, by reversed-phase HPLC. The saponin identifications were based on spectral evidence, including ¹H-¹H two-dimensional correlation spectroscopy, nuclear Overhauser and exchange spectroscopy, heteronuclear multiple quantum coherence, and heteronuclear multiple-bond connectivity experiments. The toxicity of S. langsdorffii saponins to non-target organisms was prescreened by the brine shrimp lethality test.
Subject: Swartzia langsdorffii
Leguminosae
chemotaxonomy
saponins
molluscicidal activity
schistosomiasis
Artemia salina
Editor: Instituto Oswaldo Cruz, Ministério da Saúde
Rights: aberto
Identifier DOI: 10.1590/S0074-02762003000500022
Address: http://dx.doi.org/10.1590/S0074-02762003000500022
http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762003000500022
Date Issue: 1-Jul-2003
Appears in Collections:Unicamp - Artigos e Outros Documentos

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