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Type: Artigo de periódico
Title: Pharmacokinetic profile of two different pharmaceutical forms of theophylline (a slow release tablet and a syrup) after multiple dose administration to healthy human volunteers
Author: Muscará, Marcelo Nicolás
Hofstätter, Eduardo Alexandre
Nucci, Gilberto de
Abstract: Due to the narrow therapeutic range of theophyline, plasma concentrations of this drug are monitored in patients undergoing chronic therapy. Slow-release preparations avoid the fluctuations in plasma levels and improve patient compliance. In this study, we have compared the pharmacokinetic profiles of a theophylline slow-release tablet and a syrup form, when administered in multiple doses to healthy adult volunteers. The classification based upon releasing patterns is confirmed.
Subject: theophylline
plasma levels
slow-release preparation
Editor: Instituto Oswaldo Cruz, Ministério da Saúde
Rights: aberto
Identifier DOI: 10.1590/S0074-02761993000100024
Date Issue: 1-Mar-1993
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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