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Type: Artigo de periódico
Title: Response of drug resistant isolates of Schistosoma mansoni to antischistosomal agents
Author: Drescher, Kristen M.
Rogers, Eugene J.
Bruce, John I.
Katz, Naftale
Dias, Luiz Candido de Souza
Coles, Gerald C.
Abstract: The susceptibility of four isolates of Schistosoma mansoni (BH, MAP, MPR-1 and K) to four multiple doses of anti-schistosomal agents (hycanthone, niridazole, oxamniquire, and praziquantel) were evaluated in infected female Swiss albino mice. These schistosomal isolates had been maintained in the laboratory without further drug pressure for 20 to 30 generations. Multiple dosage regimens were used for each drug against each isolate of S. mansoni to generate ED50 (effective dose 50%) values. Results demonstrated that the K isolate is resistant to niridazole, the MPR-1 isolate to oxamniquine, and the MAP isolate to both hycanthone and oxamniquine. The BH isolate was susceptible to all drugs and was used as the reference isolate. All isolates were susceptible to praziquantel. The significance of the difference in response of the MPR-1 and MAP isolates is discussed. These results confirm the resistance of these isolates of S. mansoni of three schistosomicides and demonstrate that the resistance of these isolates are stable over long periods of time without exposure to drugs.
Subject: Schistosoma mansoni
schistosome isolates (BH, MAP, K and MPR-1)
Editor: Instituto Oswaldo Cruz, Ministério da Saúde
Rights: aberto
Identifier DOI: 10.1590/S0074-02761993000100014
Date Issue: 1-Mar-1993
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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