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Type: Artigo de periódico
Title: Genetic complementation analysis of two independently isolated hycanthone-resistant strains of Schistosoma mansoni
Author: Pica-Mattoccia, Livia
Dias, Luiz Candido de Souza
Cioli, Donato
Abstract: The objective of this study is to determine whether various hycanthone resistant strains of schistosomes which have been independently isolated are all affected in the same gene. A strain obtained from a Brazilian patient was compared with a strain of Puerto Rican origin selected in the laboratory. If the mutation conferring resistance involved two different genes, one would expect that the progeny of a cross between the two strains would show complementation, i.e. it would be sensitive to the drug. We have performed such a cross and obtained F1 hybrid worms wich were essentially all resistant, thus suggesting that the mutation conferring resistance in the two strains involves the same gene.
Subject: Schistosoma mansoni
hycanthone resistance
genetic complementation
Editor: Instituto Oswaldo Cruz, Ministério da Saúde
Rights: aberto
Identifier DOI: 10.1590/S0074-02761992000800032
Date Issue: 1-Jan-1992
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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