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Type: Artigo de periódico
Title: Olfactory impairment in familial ataxias
Author: Moscovich, Mariana
Munhoz, Renato Puppi
Teive, Helio A.
Raskin, Salmo
Carvalho, Margarete de J.
Barbosa, Egberto R.
Ranvaud, Ronald
Liu, Jilin
McFarland, Karen
Ashizawa, Tetsuo
Lees, Andrew J.
Silveira-Moriyama, Laura
Abstract: The main clinical manifestations of the spinocerebellar ataxias (SCAs) result from the involvement of the cerebellum and its connections. Cerebellar activity has been consistently observed in functional imaging studies of olfaction, but the anatomical pathways responsible for this connection have not yet been elucidated. Previous studies have demonstrated olfactory deficit in SCA2, Friedreich's ataxia and in small groups of ataxia of diverse aetiology. The authors used a validated version of the 16-item smell identification test from Sniffin' Sticks (SS-16) was used to evaluate 37 patients with genetically determined autosomal dominant ataxia, and 31 with familial ataxia of unknown genetic basis. This data was also compared with results in 106 Parkinson's disease patients and 218 healthy controls. The SS-16 score was significantly lower in ataxia than in the control group (p<0.001, 95% CI for beta=0.55 to 1.90) and significantly higher in ataxia than in Parkinson's disease (p<0.001, 95% CI for beta=-4.58 to -3.00) when adjusted for age (p=0.001, 95% CI for beta=-0.05 to -0.01), gender (p=0.19) and history of tobacco use (p=0.41). When adjusted for general cognitive function, no significant difference was found between the ataxia and control groups. This study confirms previous findings of mild hyposmia in ataxia, and further suggests this may be due to general cognitive deficits rather than specific olfactory problems.
Editor: Bmj Publishing Group
Citation: Journal of Neurology Neurosurgery and Psychiatry. Bmj Publishing Group, v.83, n.10, p.970-974, 2012
Rights: fechado
Identifier DOI: 10.1136/jnnp-2012-302770
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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