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Type: Artigo de periódico
Title: Obesity and Excess Protein and Carbohydrate Consumption Are Risk Factors for Thyroid Cancer
Author: Marcello, Marjory Alana
Sampaio, Aline Castaldi
Geloneze, Bruno
Junqueira Vasques, Ana Carolina
Montalli Assumpcao, Ligia Vera
Ward, Laura Sterian
Abstract: Conflicting data concerning the association between obesity and differentiated thyroid cancer (DTC) may be attributed to the lack of records showing dietary intake and inadequate evaluation of nutrient composition. We evaluated 115 DTC patients carefully paired with 103 healthy control individuals by using a structured questionnaire, including a 24-h recordatory during 3 days, to investigate calorie intake and macronutrient (proteins, carbohydrates, and lipids) composition of the diet. We observed that excess weight (body mass index > 25 kg/m(2)) increased individual susceptibility to DTC [odds ratio (OR) = 3.787; 95% confidence interval (CI) = 1.115-6.814; P < 0.0001). This augmented risk was evident in women (OR = 1.925; 95% CI = 1.110-3.338; P = 0.0259) but not in men (P = 0.3498). Excess calorie intake was more frequent in patients with DTC than in controls (OR = 5.890; 95% CI = 3.124-11.103; P < 0.0001), and both excess protein (OR = 4.601; 95% CI = 1.634-12.954; P = 0.0039) and carbohydrate (OR = 4.905; 95% CI = 2.593-9.278; P < 0.0001) consumption were associated with an increased risk of DTC, contrarily to lipid/fiber intake and physical activity (P = 0.894 and 0.5932, respectively). In conclusion, our data indicate that overweight and risk of DTC are associated with higher protein and carbohydrate consumption than the rates recommended by the World Health Organization. The nutritional orientation should be part of preventive strategy targets designed to combat the increasing incidence of both obesity and DTC.
Editor: Routledge Journals, Taylor & Francis Ltd
Citation: Nutrition and Cancer-An International Journal. Routledge Journals, Taylor & Francis Ltd, v.64, n.8, p.1190-1195, 2012
Rights: fechado
Identifier DOI: 10.1080/01635581.2012.721154
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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