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Type: Artigo de periódico
Title: Is it just lactose intolerance?
Author: Olivier, Celso Eduardo
Silva Lorena, Sonia Leticia
Pavan, Celia Regina
Pereira Goncalves dos Santos, Raquel Acacia
dos Santos Lima, Regiane Patussi
Pinto, Daiana Guedes
da Silva, Mariana Dias
Zollner, Ricardo de Lima
Abstract: Acquired delayed-onset hypolactasia is a common autosomal recessive condition. Cow's milk allergies, conversely, are less common conditions that may manifest with equivalent symptoms and are able to simulate and/or aggravate lactose intolerance. This study was designed to evaluate the contribution of IgE-mediated cow's milk sensitization to the symptomatology of adult patients with lactose-free diet refractory lactose intolerance. Forty-six adult patients with lactose intolerance and persistent symptoms despite a lactose-free diet underwent skin-prick test to investigate cow's milk, goat's milk, and soy protein-specific-IgE. SDS-PAGE immunoblotting was used to investigate the presence of cow's milk protein-specific IgE. The percentage of patients who had skin reactions to whole cow's milk, alpha-lactalbumin, beta-lactoglobulin, caseins, goat's milk, and soy was 69.5, 36.9, 56.5, 56.5%, 54.3, and 50%, respectively. The percentage of patients with immunoblot-detected IgE specific for alpha-lactalbumin, beta-lactoglobulin, caseins, and bovine serum albumin was 21.7, 63, 67.3, and 2.1%, respectively. IgE -mediated sensitization to cow's milk is a frequent comorbidity in subjects with lactose-free diet refractory lactose intolerance and is worth consideration in patients with this condition. (Allergy Asthma Proc 33:432-436, 2012; doi: 10.2500/aap.2012.33.3584)
Editor: Ocean Side Publications Inc
Rights: fechado
Identifier DOI: 10.2500/aap.2012.33.3584
Date Issue: 2012
Appears in Collections:FCM - Artigos e Outros Documentos

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