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Type: Artigo de periódico
Title: Antimicrobial Activity of Diterpenes from Viguiera arenaria against Endodontic Bacteria
Author: CARVALHO, Tatiane C.
SIMAO, Marilia R.
FURTADO, Niege A. J. C.
VENEZIANI, Rodrigo C. S.
HELENO, Vladimir C. G.
COSTA, Fernando B. Da
GOMES, Brenda P. F. A.
SOUZA, Maria Gorete M.
REIS, Erika Borges dos
MARTINS, Carlos H. G.
Abstract: Six pimarane-type diterpenes isolated from Viguiera arenaria Baker and two semi-synthetic derivatives were evaluated in vitro against a panel of representative microorganisms responsible for dental root canal infections. The microdilution method was used for the determination of the minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) against Porphyromonas gingivalis, Prevotella nigrescens, Prevotella intermedia, Prevotella buccae, Fusobacterium nucleatum, Bacteroides fragilis, Actinomyces naeslundii, Actinomyces viscosus, Peptostreptococcus micros, Enterococcus faecalis and Aggregatibacter actinomycetemcomitans. The compounds ent-pimara-8(14), 15-dien-19-oic acid, its sodium salt and ent-8(14), 15-pimaradien-3 beta-ol were the most active, displaying MIC values ranging from 1 to 10 mu g mL(-1). The results also allow us to conclude that minor structural differences among these diterpenes significantly influence their antimicrobial activity, bringing new perspectives to the discovery of new chemicals for use as a complement to instrumental endodontic procedures.
Subject: antimicrobial activity
endodontic bacteria
pimarane diterpenes
structural requirements
Viguiera arenaria
Country: Suiça
Editor: MDPI AG
Citation: MOLECULES, v.16, n.1, p.543-551, 2011
Rights: aberto
Identifier DOI: 10.3390/molecules160100543
Date Issue: 2011
Appears in Collections:FOP - Artigos e Materiais de Revistas Científicas

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