Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/2109
Type: Artigo de periódico
Title: Association of HLA-DRB5*01 with protection against cutaneous manifestations of rheumatoid vasculitis in Brazilian patients
Author: Nishimura, Wester Eidi
Lavras Costallat, Lilian Tereza
Muchinechi Fernandes, Sandra Regina
Conde, Roseneide Aparecida
Bertolo, Manoel Barros
Abstract: Objective: To evaluate the frequency of HLA classes I and II and their association with the cutaneous manifestation of rheumatoid vasculitis (RV) in Brazilian patients. Patients and methods: During one year we selected 130 patients with rheumatoid arthritis (RA) classified according to the American College of Rheumatology, 1987. All patients underwent a clinical and laboratory questionnaire to exclude other causes of cutaneous vasculopathy (neoplasia, infections, illicit drug use, diabetes mellitus, and tobaccoism). Seventy-three patients with any risk factor for other causes of vasculopathy were excluded. Fifty-seven without risk factors for other causes of vasculopathy were included in the study, 17 with RV according to Scott and Bacon's criteria, 1984. Demographic data, time of RA diagnosis, disease activity (DAS28), presence of rheumatoid factor, and anti-cyclic citrullinated peptide antibodies were analyzed. The HLA alleles were typed using the DNA-amplified polymerase chain reaction with low-resolution hybridization and sequence-specific primers. Results: The comparison between the 40 patients without RV and the 17 patients with RV showed an increased frequency of HLAB*14 (Pc = 0.168) and HLA-Cw*08 (Pc = 0.084) in patients with RV and an increased frequency of HLA-DRB5*01 (Pc = 0.048) in patients without RV. Conclusion: The HLA-DRB5*01 may confer protection against that extra-articular manifestation of RA.
Subject: rheumatoid vasculitis
HLA antigens
disease susceptibility
protection
Editor: Elsevier
Rights: fechado
Date Issue: 2012
Appears in Collections:FCM - Artigos e Materiais de Revistas Científicas

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