Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/2073
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleThe increased PDGF-A, PDGF-B and FGF-2 expression in recurrence of salivary gland pleomorphic adenomapt_BR
dc.contributor.authorSoares, Andresa Borgespt_BR
dc.contributor.authorDemasi, Ana Paulapt_BR
dc.contributor.authorTincani, Alfio Josept_BR
dc.contributor.authorMartins, Antonio Santospt_BR
dc.contributor.authorAltemani, Albinapt_BR
dc.contributor.authorde Araujo, Vera Cavalcantipt_BR
unicamp.authorTincani, Alfio Josept_BR
unicamp.authorMartins, Antonio Santospt_BR
unicamp.authorAltemani, Albinapt_BR
unicamp.author.externalSoares, Andresa Borgespt
unicamp.author.externalDemasi, Ana Paulapt
unicamp.author.externalde Araujo, Vera Cavalcantipt
dc.subject.wosGROWTH-FACTOR RECEPTORpt_BR
dc.subject.wosPAROTID-GLANDpt_BR
dc.subject.wosIN-VIVOpt_BR
dc.subject.wosCELLSpt_BR
dc.subject.wosTRANSFORMATIONpt_BR
dc.subject.wosCARCINOMApt_BR
dc.subject.wosFAMILYpt_BR
dc.subject.wosCANCERpt_BR
dc.subject.wosSTROMApt_BR
dc.description.abstractBackground Pleomorphic adenoma (PA) is the most common salivary gland tumour. Although classified as benign, it has a tendency to recur (recurrent pleomorphic adenomas (RPA)), as well as the ability to undergo malignant transformation. It has been suggested that mutations in various families of growth factors and growth factor receptions are involved in the autonomous growth of tumour cells. The aim of the present study was to investigate the participation of platelet-derived growth factor (PDGF)-A, PDGF-B, PDGF-R alpha, fibroblast growth factor (FGF)-2, Flg and BEK in PA, RPA and recurrent pleomorphic adenoma with malignant transformation (TRPA). Methods 18 cases of PA, 16 cases of RPA and two cases of RPA with focal malignant transformation (TRPA) were analysed for growth factor expression utilising immunohistochemical techniques via tissue microarray. Results There was a significant difference in PDGF-A, PDGF-B, PDGF-R alpha, FGF-2, Flg and BEK expression in all groups. When comparing non-recurrent with recurrent tumours, PDGF-A, PDGF-B, PDGF-R alpha, FGF-2, Flg and BEK reactivity in RPA was stronger than that observed in PA. All proteins were highly expressed in TRPA. Conclusions This research suggests that PDGF-A, PDGF-B, PDGF-R alpha, FGF-2, BEK and Flg can be related to the recurrence of PA. In addition, this study shows that TRPA cells overexpress all growth factors, which has been reported in association with the malignant transformation.pt
dc.relation.ispartofJournal of Clinical Pathologypt_BR
dc.publisher.cityLondonpt_BR
dc.publisherB M J Publishing Grouppt_BR
dc.date.issued2012pt_BR
dc.identifier.citationJournal of Clinical Pathology. B M J Publishing Group, v.65, n.3, p.272-277, 2012pt_BR
dc.language.isoengpt_BR
dc.description.volume65pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage272pt_BR
dc.description.lastpage277pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0021-9746pt_BR
dc.identifier.wosidWOS:000300623700016pt_BR
dc.identifier.doi10.1136/jclinpath-2011-200405pt_BR
dc.description.sponsorshipFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2013-09-19T18:06:20Z
dc.date.available2016-07-01T15:40:06Z-
dc.date.accessioned2013-09-19T18:06:20Z
dc.date.accessioned2016-07-01T15:40:06Z-
dc.description.provenanceMade available in DSpace on 2013-09-19T18:06:20Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.description.provenanceMade available in DSpace on 2016-07-01T15:40:06Z (GMT). No. of bitstreams: 0 Previous issue date: 2012en
dc.identifier.urihttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/2073
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/2073-
dc.contributor.departmentCirurgia
dc.contributor.unidadeFCMpt
Appears in Collections:FCM - Artigos e Outros Documentos

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