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|Type:||Artigo de periódico|
|Title:||Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity|
|Author:||Reddy, Kachi R. Kishore Kumar|
Longato, Giovanna B.
de Carvalho, Joao E.
Ruiz, Ana L. T. G.
Silva, Luiz F., Jr.
|Abstract:||An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI(50) = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered.|
|Citation:||Molecules. Mdpi Ag, v.17, n.8, p.9621-9630, 2012|
|Appears in Collections:||CPQBA - Artigos e Outros Documentos|
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