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Type: Artigo de periódico
Title: Populene D Analogues: Design, Concise Synthesis and Antiproliferative Activity
Author: Reddy, Kachi R. Kishore Kumar
Longato, Giovanna B.
de Carvalho, Joao E.
Ruiz, Ana L. T. G.
Silva, Luiz F., Jr.
Abstract: An efficient and concise synthesis of nine populene D analogues was performed using an iodine-catalyzed Prins cyclization as the key transformation. The antiproliferative activity of these new pyrans against several cancer cell lines was then investigated. Among them, an isochromene with moderate activity (mean logGI(50) = 0.91) was found. Additionally, compounds with selectivity toward the tumor cell lines NCI-ADR/RES, OVCAR-3, and HT29 were discovered.
Subject: osochromene
Prins cyclization
Editor: Mdpi Ag
Citation: Molecules. Mdpi Ag, v.17, n.8, p.9621-9630, 2012
Rights: fechado
Identifier DOI: 10.3390/molecules17089621
Date Issue: 2012
Appears in Collections:CPQBA - Artigos e Outros Documentos

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