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Type: Artigo de periódico
Title: Desenvolvimento, produção e caracterização de nanocristais de fármacos pouco solúveis
Title Alternative: Development, production and characterization of nanocrystals of poorly soluble drugs
Author: Fangueiro, Joana F.
Marques, Inês R.
Severino, Patrícia
Santana, Maria Helena A.
Souto, Eliana B.
Abstract: Poorly soluble drugs have low bioavailability, representing a major challenge for the pharmaceutical industry. Processing drugs into the nanosized range changes their physical properties, and these are being used in pharmaceutics to develop innovative formulations known as Nanocrystals. Use of nanocrystals to overcome the problem of low bioavailability, and their production using different techniques such as microfluidization or high pressure homogenization, was reviewed in this paper. Examples of drugs, cosmetics and nutraceutical ingredients were also discussed. These technologies are well established in the pharmaceutical industry and are approved by the Food and Drug Administration.
Subject: nancrystals
high pressure homogenization
Editor: Sociedade Brasileira de Química
Rights: aberto
Identifier DOI: 10.1590/S0100-40422012000900025
Date Issue: 1-Jan-2012
Appears in Collections:Unicamp - Artigos e Outros Documentos

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