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Type: Artigo de periódico
Title: Antimycobacterial and cytotoxicity activity of synthetic and natural compounds
Author: Souza, Ana O. de
Galetti, Fabio C. S.
Silva, Célio L.
Bicalho, Beatriz
Parma, Márcia M.
Fonseca, Sebastião F.
Marsaioli, Anita J.
Trindade, Angela C. L. B.
Gil, Rossimíriam P. Freitas
Bezerra, Franciglauber S.
Andrade-Neto, Manoel
Oliveira, Maria C. F. de
Abstract: Antimycobacterial and cytotoxicity activity of synthetic and natural compounds. Secondary metabolites from Curvularia eragrostidis and Drechslera dematioidea, Clusia sp. floral resin, alkaloids from Pilocarpus alatus, salicylideneanilines, piperidine amides, the amine 1-cinnamylpiperazine and chiral pyridinium salts were assayed on Mycobacterium tuberculosis H37Rv. N-(salicylidene)-2-hydroxyaniline was the most effective compound with a minimal inhibitory concentration (MIC) of 8 µmol/L. Dihydrocurvularin was moderately effective with a MIC of 40 µmol/L. Clusia sp. floral resin and a gallocatechin-epigallocatechin mixture showed MIC of 0.02 g/L and 38 µmol/L, respectively. The cytotoxicity was evaluated for N-(salicylidene)-2-hydroxyaniline, curvularin, dihydrocurvularin and Clusia sp. floral resin, and the selectivity indexes were > 125, 0.47, 0.75 and 5, respectively.
Subject: antimycobacterial activity
natural products
synthetic products
Editor: Sociedade Brasileira de Química
Citation: Química Nova. Sociedade Brasileira de Química, v. 30, n. 7, p. 1563-1566, 2007.
Rights: aberto
Identifier DOI: 10.1590/S0100-40422007000700012
Date Issue: 1-Jan-2007
Appears in Collections:Unicamp - Artigos e Outros Documentos

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