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dc.contributor.CRUESPUniversidade Estadual de Campinaspt_BR
dc.typeArtigo de periódicopt_BR
dc.titlePARAFAC: uma ferramenta quimiométrica para tratamento de dados multidimensionais. Aplicações na determinação direta de fármacos em plasma humano por espectrofluorimetriapt_BR
dc.title.alternativePARAFAC: a chemometric tool for multi-dimensional data treatment. Applications in direct determination of drugs in human plasma by spectrofluorimetryen
dc.contributor.authorSena, Marcelo M.pt_BR
dc.contributor.authorTrevisan, Marcello G.pt_BR
dc.contributor.authorPoppi, Ronei J.pt_BR
unicamp.authorSena, Marcelo M.pt_BR
unicamp.authorTrevisan, Marcello G. Universidade Estatual de Campinas Estadual de Campinas Instituto de Químicapt_BR
unicamp.authorPoppi, Ronei J. Universidade Estatual de Campinas Estadual de Campinas Instituto de Químicapt_BR
dc.subjectparallel factor analysispt_BR
dc.subjecthuman bloodpt_BR
dc.subjectmolecular fluorescencept_BR
dc.description.abstractSince the last decade, the combined use of chemometrics and molecular spectroscopic techniques has become a new alternative for direct drug determination, without the need of physical separation. Among the new methodologies developed, the application of PARAFAC in the decomposition of spectrofluorimetric data should be highlighted. The first objective of this article is to describe the theoretical basis of PARAFAC. For this purpose, a discussion about the order of chemometric methods used in multivariate calibration and the development of multi-dimensional methods is presented first. The other objective of this article is to divulge for the Brazilian chemical community the potential of the combination PARAFAC/spectrofluorimetry for the determination of drugs in complex biological matrices. For this purpose, two applications aiming at determining, respectively, doxorrubicine and salicylate in human plasma are presented.en
dc.relation.ispartofQuímica Novapt_BR
dc.publisherSociedade Brasileira de Químicapt_BR
dc.identifier.citationQuímica Nova. Sociedade Brasileira de Química, v. 28, n. 5, p. 910-920, 2005.pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.provenanceMade available in DSpace on 2015-12-03T13:30:24Z (GMT). No. of bitstreams: 2 S0100-40422005000500032.pdf: 499088 bytes, checksum: 3b51e02581a5ae637812c712361c7a25 (MD5) S0100-40422005000500032.pdf.txt: 66742 bytes, checksum: 91e9ddbc1e292f1e52bf9ec4b08af1e4 (MD5) Previous issue date: 2005-10-01en
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