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Type: Artigo de periódico
Title: P16(ink) (4a) Expression As A Potential Marker Of Low-grade Cervical Intraepithelial Neoplasia Progression.
Author: da Costa, Larissa Bastos Eloy
Triglia, Renata De Marchi
França Junior, Marcondes Cavalcante
Andrade, Liliana A Lucci De Angelo
Abstract: To evaluate p16(INK) (4a) immunoexpression in CIN1 lesions looking for differences between cases that progress to CIN2/3 maintain CIN1 diagnosis, or spontaneously regress. Seventy-four CIN1 biopsies were studied. In the follow-up, a second biopsy was performed and 28.7% showed no lesion (regression), 37.9% maintained CIN1, and 33.4% progressed to CIN2/3. Immunostaining for p16(INK) (4a) was performed in the first biopsy and it was considered positive when there was strong and diffuse staining of the basal and parabasal layers. Pearson's chi-square was used to compare the groups (p ≤ 0.05). The age of the patients was similar. There was no significant difference in p16(INK) (4a) immunoexpression in the groups, however, statistical analyses showed a significant association when only the progression and regression groups were compared (p = 0.042). Considering p16(INK) (4a) positivity and the progression to CIN2/3, the sensitivity, specificity, positive, and negative predictive values in our cohort were 45%, 75%, 47%, and 94%, respectively. We emphasize that CIN1 with p16(INK) (4a) staining was associated with lesion progression, but the sensitivity was not high. However, the negative predictive value was more reliable (94%) and p16(INK) (4a) may represent a useful biomarker that can identify CIN1 lesions that need particular attention, complementing morphology.
Subject: Cin Progression
Cervical Intraepithelial Neoplasia
Citation: Apmis : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica. v. 123, n. 3, p. 185-9, 2015-Mar.
Rights: fechado
Identifier DOI: 10.1111/apm.12338
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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