Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/202306
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.typeArtigo de periódicopt_BR
dc.titleClinical Influence Of Different Intracanal Medications On Th1-type And Th2-type Cytokine Responses In Apical Periodontitis.pt_BR
dc.contributor.authorMartinho, Frederico Cpt_BR
dc.contributor.authorNascimento, Gustavo Gpt_BR
dc.contributor.authorLeite, Fabio R Mpt_BR
dc.contributor.authorGomes, Ana P Mpt_BR
dc.contributor.authorFreitas, Lilian Fpt_BR
dc.contributor.authorCamões, Izabel C Gpt_BR
unicamp.authorDepartment of Restorative Dentistry, Endodontics Division, Piracicaba Dental School-State University of Campinas-UNICAMP, Piracicaba, São Paulo, Brazil. Electronic address: Frederico.martinho@fosjc.unesp.br.pt_BR
unicamp.author.externalFrederico C Martinho, Department of Restorative Dentistry, Endodontics Division-UNESP-UNIV Estadual Paulista, São José dos Campos Dental School, São José dos Campos, São Paulo, Brazilpt
unicamp.author.externalGustavo G Nascimento, Department of Semiology and Clinics, Periodontics Division, Federal University of Pelotas Dental School, Pelotas, Rio Grande do Sul, Brazil.pt
unicamp.author.externalFabio R M Leite, Department of Semiology and Clinics, Periodontics Division, Federal University of Pelotas Dental School, Pelotas, Rio Grande do Sul, Brazil.pt
unicamp.author.externalAna P M Gomes, Department of Restorative Dentistry, Endodontics Division-UNESP-UNIV Estadual Paulista, São José dos Campos Dental School, São José dos Campos, São Paulo, Brazil.pt
unicamp.author.externalLilian F Freitas, Department of Restorative Dentistry, Endodontic Division, Fluminense Federal University (UFF), Niteroi, Rio de Janeiro, Brazil.pt
unicamp.author.externalIzabel C G Camões, Department of Restorative Dentistry, Endodontic Division, Fluminense Federal University (UFF), Niteroi, Rio de Janeiro, Brazil.pt
dc.subjectDisinfectionpt_BR
dc.subjectEndodonticspt_BR
dc.subjectMedicationpt_BR
dc.subjectRoot Canalpt_BR
dc.description.abstractThis clinical study assessed the influence of different intracanal medications on Th1-type and Th2-type cytokine responses in apical periodontitis and monitored the levels of bacteria from primarily infection during endodontic procedures. Thirty primarily infected teeth were randomly divided into 3 groups according to the medication selected: chlorhexidine (CHX), 2% CHX gel; Ca(OH)2/SSL, Ca(OH)2 + SSL; and Ca(OH)2/CHX, Ca(OH)2 + 2% CHX gel (all, n = 10). Bacterial sample was collected from root canals, and the interstitial fluid was sampled from lesions. Culture techniques were used to determine bacterial counts (colony-forming units/mL). Th1 (tumor necrosis factor-α, interferon-γ, and interleukin [IL]-2) and Th2 cytokines (IL-4, IL-5, and IL-13) were measured by enzyme-linked immunosorbent assay. All intracanal medication protocols were effective in reducing the bacterial load from root canals (all P < .05) and lowering the levels of Th1-type cytokines in apical lesions (all P < .05), with no differences between them (P > .05). Both Ca(OH)2 treatment protocols significantly increased the levels of Th2-type cytokines (P < .05), with no differences between them (P > .05). Thus, chlorhexidine medication showed the lowest effectiveness in increasing the levels of Th2-type cytokine. After treatment, regardless of the type of medication, the linear regression analysis indicated the down-regulation of Th2-type cytokines by Th1-type cytokines. All intracanal medication protocols were effective in reducing bacterial load and lowering the levels of Th1-type cytokines. Thus, the use of Ca(OH)2 medications contributed to the increase in the Th2-type cytokine response in apical periodontitis.en
dc.relation.ispartofJournal Of Endodonticspt_BR
dc.relation.ispartofabbreviationJ Endodpt_BR
dc.date.issued2015-Febpt_BR
dc.identifier.citationJournal Of Endodontics. v. 41, n. 2, p. 169-75, 2015-Feb.pt_BR
dc.language.isoengpt_BR
dc.description.volume41pt_BR
dc.description.firstpage169-75pt_BR
dc.rightsfechadopt_BR
dc.rights.holderCopyright © 2015 American Association of Endodontists. Published by Elsevier Inc. All rights reserved.pt_BR
dc.sourcePubMedpt_BR
dc.identifier.issn1878-3554pt_BR
dc.identifier.doi10.1016/j.joen.2014.09.028pt_BR
dc.identifier.urlhttp://www.ncbi.nlm.nih.gov/pubmed/25453567pt_BR
dc.date.available2015-11-27T13:46:43Z-
dc.date.accessioned2015-11-27T13:46:43Z-
dc.description.provenanceMade available in DSpace on 2015-11-27T13:46:43Z (GMT). No. of bitstreams: 1 pmed_25453567.pdf: 252959 bytes, checksum: e7eb0e11ce4b015b11fed736d84d838f (MD5) Previous issue date: 2015en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/202306-
dc.identifier.idPubmed25453567pt_BR
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