Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/202290
Type: Artigo de periódico
Title: Bipolar Disorder: Recent Advances And Future Trends In Bioanalytical Developments For Biomarker Discovery.
Author: de Jesus, Jemmyson Romário
de Campos, Bruna Kauely
Galazzi, Rodrigo Moretto
Martinez, José Luis Capelo
Arruda, Marco Aurélio Zezzi
Abstract: In this manuscript we briefly describe bipolar disorder (a depressive and manic mental disease), its classification, its effects on the patient, which sometimes include suicidal tendencies, and the drugs used for treatment. We also address the status quo with regard to diagnosis of bipolar disorder and recent advances in bioanalytical approaches for biomarker discovery. These approaches focus on blood samples (serum and plasma) and proteins as the main biomarker targets, and use various strategies for protein depletion. Strategies include use of commercially available kits or other homemade strategies and use of classical proteomics methods for protein identification based on bottom-up or top-down approaches, which used SELDI, ESI, or MALDI as sources for mass spectrometry, and up-to-date mass analyzers, for example Orbitrap. We also discuss some future objectives for treatment of this disorder and possible directions for the correct diagnosis of this still-unclear mental illness.
Rights: fechado
Identifier DOI: 10.1007/s00216-014-8341-3
Address: http://www.ncbi.nlm.nih.gov/pubmed/25433685
Date Issue: 2015
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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