Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/202267
Type: Artigo de periódico
Title: Combining Xanthan And Chitosan Membranes To Multipotent Mesenchymal Stromal Cells As Bioactive Dressings For Dermo-epidermal Wounds.
Author: Bellini, Márcia Z
Caliari-Oliveira, Carolina
Mizukami, Amanda
Swiech, Kamilla
Covas, Dimas T
Donadi, Eduardo A
Oliva-Neto, Pedro
Moraes, Ângela M
Abstract: The association between tridimensional scaffolds to cells of interest has provided excellent perspectives for obtaining viable complex tissues in vitro, such as skin, resulting in impressive advances in the field of tissue engineering applied to regenerative therapies. The use of multipotent mesenchymal stromal cells in the treatment of dermo-epidermal wounds is particularly promising due to several relevant properties of these cells, such as high capacity of proliferation in culture, potential of differentiation in multiple skin cell types, important paracrine and immunomodulatory effects, among others. Membranes of chitosan complexed with xanthan may be potentially useful as scaffolds for multipotent mesenchymal stromal cells, given that they present suitable physico-chemical characteristics and have adequate tridimensional structure for the adhesion, growth, and maintenance of cell function. Therefore, the purpose of this work was to assess the applicability of bioactive dressings associating dense and porous chitosan-xanthan membranes to multipotent mesenchymal stromal cells for the treatment of skin wounds. The membranes showed to be non-mutagenic and allowed efficient adhesion and proliferation of the mesenchymal stromal cells in vitro. In vivo assays performed with mesenchymal stromal cells grown on the surface of the dense membranes showed acceleration of wound healing in Wistar rats, thus indicating that the use of this cell-scaffold association for tissue engineering purposes is feasible and attractive.
Subject: Scaffolds
Chitosan
Dressings
Regenerative Medicine
Skin Lesions
Stem Cells
Xanthan Gum
Rights: fechado
Identifier DOI: 10.1177/0885328214553959
Address: http://www.ncbi.nlm.nih.gov/pubmed/25281644
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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