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Type: Artigo de periódico
Title: Association Between Cationic Liposomes And Low Molecular Weight Hyaluronic Acid.
Author: Gasperini, Antonio A M
Puentes-Martinez, Ximena E
Balbino, Tiago Albertini
de Paula Rigoletto, Thais
de Sá Cavalcanti Corrêa, Gabriela
Cassago, Alexandre
Portugal, Rodrigo Villares
de La Torre, Lucimara Gaziola
Cavalcanti, Leide P
Abstract: This work presents a study of the association between low molecular weight hyaluronic acid (16 kDa HA) and cationic liposomes composed of egg phosphatidylcholine (EPC), 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine (DOPE), and 1,2-dioleoyl-3-trimethylammonium-propane (DOTAP). The cationic liposome/HA complexes were evaluated to determine their mesoscopic structure, average size, zeta potential, and morphology as a function of the amount of HA in the system. Small angle X-ray scattering results revealed that neighboring cationic liposomes either stick together after a partial coating of low concentration HA or disperse completely in excess of HA, but they never assemble as multilamellar vesicles. Cryo-transmission electron microscopy images confirm the existence of unilamellar vesicles and large aggregates of unilamellar vesicles for HA fractions up to 80% (w/w). High concentrations of HA (> 20% w/w) proved to be efficient for coating extruded liposomes, leading to particle complexes with sizes in the nanoscale range and a negative zeta potential.
Citation: Langmuir : The Acs Journal Of Surfaces And Colloids. v. 31, n. 11, p. 3308-17, 2015-Mar.
Rights: fechado
Identifier DOI: 10.1021/la5045865
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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