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Type: Artigo de periódico
Title: Bioactivity And Chemical Composition Of The Essential Oil From The Leaves Of Guatteria Australis
Author: Siqueira, Carlos Alberto Theodoro
Serain, Alessandra Freitas
Pascoal, Aislan Cristina Rheder Fagundes
Andreazza, Nathalia Luiza
de Lourenço, Caroline Caramano
Góis Ruiz, Ana Lúcia T
de Carvalho, João Ernesto
de Souza, Ana Cláudia Oliveira
Tonini Mesquita, Juliana
Tempone, Andre Gustavo
Salvador, Marcos José
Abstract: Essential oil from the leaves of Guatteria australis was obtained by hydrodistillation, analyzed by Gas Chromatography coupled to Mass Spectromery (GC-MS) and their antiproliferative, antileishmanial, antibacterial, antifungal and antioxidant activities were also evaluated. Twenty-three compounds were identified among which germacrene B (50.66%), germacrene D (22.22%) and (E)-caryophyllene (8.99%) were the main compounds. The highest antiproliferative activity was observed against NCI-ADR/RES (TGI = 31.08 μg/ml) and HT-29 (TGI = 32.81 μg/ml) cell lines. It also showed good antileishmanial activity against Leishmania infantum (IC50 = 30.71 μg/ml). On the other hand, the oil exhibited a small effect against Staphylococcus aureus ATCC 6538, S. aureus ATCC 14458 and Escherichia coli ATCC 10799 (MIC = 250 μg/ml), as well as small antioxidant activity (457 μmol TE/g) assessed through ORACFL assay. These results represent the first report regarding chemical composition and bioactivity of G. australis essential oil.
Subject: Annonaceae
Guatteria Australis
Essential Oil
Rights: fechado
Identifier DOI: 10.1080/14786419.2015.1015017
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

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