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dc.typeArtigo de periódicopt_BR
dc.titleIncreased Arterial Stiffness In Resistant Hypertension Is Associated With Inflammatory Biomarkers.pt_BR
dc.contributor.authorBarbaro, Natália Ruggeript_BR
dc.contributor.authorFontana, Vanessapt_BR
dc.contributor.authorModolo, Rodrigopt_BR
dc.contributor.authorDe Faria, Ana Paulapt_BR
dc.contributor.authorSabbatini, Andrea Rodriguespt_BR
dc.contributor.authorFonseca, Francisco Helfensteinpt_BR
dc.contributor.authorAnhê, Gabriel Fpt_BR
dc.contributor.authorMoreno, Heitorpt_BR
unicamp.authorNatália Ruggeri Barbaro, Laboratory of Cardiovascular Pharmacology, Faculty of Medical Sciences, University of Campinas (Unicamp) , Campinas , Brazil.pt_BR Fontana,pt Modolo,pt Paula De Faria,pt Rodrigues Sabbatini,pt Helfenstein Fonseca,pt F Anhê,pt Moreno,pt
dc.subjectArterial Stiffnesspt_BR
dc.subjectInflammatory Cytokinespt_BR
dc.subjectPulse Wave Velocitypt_BR
dc.subjectResistant Hypertensionpt_BR
dc.description.abstractIncreased levels of inflammatory biomarkers such as interleukin-6 (IL-6), 10 (IL-10), 1β (IL-1β), tumor necrosis factor-α (TNF-α) high-sensitivity C-reactive protein (hs-CRP) are associated with arterial stiffness in hypertension. Indeed, resistant hypertension (RHTN) leads to unfavorable prognosis attributed to poor blood pressure (BP) control and target organ damage. This study evaluated the potential impact of inflammatory biomarkers on arterial stiffness in RHTN. In this cross-sectional study, 32 RHTN, 20 mild hypertensive (HTN) and 20 normotensive (NT) patients were subjected to office BP and arterial stiffness measurements assessed by pulse wave velocity (PWV). Inflammatory biomarkers were measured in plasma samples. PWV was increased in RHTN compared with HTN and NT (p < 0.05). TNF-α levels were significantly higher in RHTN and HTN than NT patients. No differences in IL-6 levels were observed. RHTN patients had a higher frequency of subjects with increased levels of IL-10 and IL-1β compared with HTN and NT patients. Finally, IL-1β was independently associated with PWV (p < 0.001; R(2) = 0.5; β = 0.077). RHTN subjects have higher levels of inflammatory cytokines (TNF-α, IL-1β and IL-10) as well as increased arterial stiffness, and detectable IL-1β levels are associated arterial stiffness. These findings suggest that inflammation plays a possible role in the pathophysiology of RHTN.en
dc.relation.ispartofBlood Pressurept_BR
dc.relation.ispartofabbreviationBlood Press.pt_BR
dc.identifier.citationBlood Pressure. v. 24, n. 1, p. 7-13, 2015-Feb.pt_BR
dc.description.provenanceMade available in DSpace on 2015-11-27T13:45:58Z (GMT). No. of bitstreams: 0 Previous issue date: 2015en
Appears in Collections:Unicamp - Artigos e Outros Documentos

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