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Type: Artigo de periódico
Title: Seven-membered Rings Through Metal-free Rearrangement Mediated By Hypervalent Iodine.
Author: Silva, Siguara Bastos Lemos
Torre, Adriana Della
de Carvalho, João Ernesto
Ruiz, Ana Lúcia Tasca Gois
Silva, Luiz F
Abstract: A versatile and metal-free approach for the synthesis of carbocycles and of heterocycles bearing seven- and eight-membered rings is described. The strategy is based on ring expansion of 1-vinylcycloalkanols (or the corresponding silyl or methyl ether) mediated by the hypervalent iodine reagent HTIB (PhI(OH)OTs). Reaction conditions can be easily adjusted to give ring expansion products bearing different functional groups. A route to medium-ring lactones was also developed.
Rights: aberto
Identifier DOI: 10.3390/molecules20011475
Date Issue: 2015
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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