Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/202036
Type: Artigo de periódico
Title: Gut Bacteria Products Prevent Aki Induced By Ischemia-reperfusion.
Author: Andrade-Oliveira, Vinicius
Amano, Mariane T
Correa-Costa, Matheus
Castoldi, Angela
Felizardo, Raphael J F
de Almeida, Danilo C
Bassi, Enio J
Moraes-Vieira, Pedro M
Hiyane, Meire I
Rodas, Andrea C D
Peron, Jean P S
Aguiar, Cristhiane F
Reis, Marlene A
Ribeiro, Willian R
Valduga, Claudete J
Curi, Rui
Vinolo, Marco Aurelio Ramirez
Ferreira, Caroline M
Câmara, Niels Olsen Saraiva
Abstract: Short-chain fatty acids (SCFAs) are fermentation end products produced by the intestinal microbiota and have anti-inflammatory and histone deacetylase-inhibiting properties. Recently, a dual relationship between the intestine and kidneys has been unraveled. Therefore, we evaluated the role of SCFA in an AKI model in which the inflammatory process has a detrimental role. We observed that therapy with the three main SCFAs (acetate, propionate, and butyrate) improved renal dysfunction caused by injury. This protection was associated with low levels of local and systemic inflammation, oxidative cellular stress, cell infiltration/activation, and apoptosis. However, it was also associated with an increase in autophagy. Moreover, SCFAs inhibited histone deacetylase activity and modulated the expression levels of enzymes involved in chromatin modification. In vitro analyses showed that SCFAs modulated the inflammatory process, decreasing the maturation of dendritic cells and inhibiting the capacity of these cells to induce CD4(+) and CD8(+) T cell proliferation. Furthermore, SCFAs ameliorated the effects of hypoxia in kidney epithelial cells by improving mitochondrial biogenesis. Notably, mice treated with acetate-producing bacteria also had better outcomes after AKI. Thus, we demonstrate that SCFAs improve organ function and viability after an injury through modulation of the inflammatory process, most likely via epigenetic modification.
Subject: Scfa
Epigenetic Modifications
Ischemia-reperfusion
Kidney Disease
Microbiota
Rights: fechado
Identifier DOI: 10.1681/ASN.2014030288
Address: http://www.ncbi.nlm.nih.gov/pubmed/25589612
Date Issue: 2015
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
pmed_25589612.pdf1.95 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.