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Type: Artigo de periódico
Title: Antiproliferative Activity Of Synthetic Fatty Acid Amides From Renewable Resources.
Author: dos Santos, Daiane S
Piovesan, Luciana A
D'Oca, Caroline R Montes
Hack, Carolina R Lopes
Treptow, Tamara G M
Rodrigues, Marieli O
Vendramini-Costa, Débora B
Ruiz, Ana Lucia T G
de Carvalho, João Ernesto
D'Oca, Marcelo G Montes
Abstract: In the work, the in vitro antiproliferative activity of a series of synthetic fatty acid amides were investigated in seven cancer cell lines. The study revealed that most of the compounds showed antiproliferative activity against tested tumor cell lines, mainly on human glioma cells (U251) and human ovarian cancer cells with a multiple drug-resistant phenotype (NCI-ADR/RES). In addition, the fatty methyl benzylamide derived from ricinoleic acid (with the fatty acid obtained from castor oil, a renewable resource) showed a high selectivity with potent growth inhibition and cell death for the glioma cell line-the most aggressive CNS cancer.
Subject: Glioma
Multidrug Resistance
Ovarian Cancer
Ricinoleic Acid
Rights: fechado
Identifier DOI: 10.1016/j.bmc.2014.11.019
Date Issue: 2015
Appears in Collections:Artigos e Materiais de Revistas Científicas - Unicamp

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